Center for Tobacco Control Research and Education, University of California, San Francisco, 530 Parnassus Avenue, San Francisco, California 94143-1390, USA.
Tob Control. 2010 Oct;19(5):374-9. doi: 10.1136/tc.2009.033092. Epub 2010 May 27.
Low-tar cigarette smoking is gaining popularity in China. The China National Tobacco Corporation (CNTC) promotes low-tar cigarettes as safer than regular cigarettes.
A total of 543 male smokers smoking cigarettes with different tar yields (15 mg, regular cigarettes, 10-13 mg low-tar cigarettes and < 10 mg low-tar cigarettes) were recruited in Shanghai, China, who then completed a questionnaire on smoking behaviour and provided a urine sample for analysis of the nicotine metabolites cotinine and trans-3'-hydroxycotinine. A total of 177 urine samples were selected at random for the analysis of the carcinogens polycyclic aromatic hydrocarbon metabolites (PAHs) (1-hydroxypyrene, naphthols, hydroxyfluorenes and hydroxyphenanthrenes) and the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-butanone (NNK) metabolites, 4-(methylnitrosamino)-1-(3-pyridyl)-butanol (NNAL) and NNAL-glucuronide. Values were normalised by creatinine to correct for possible distortions introduced by dilution or concentration of the urine.
Smokers of low-tar cigarettes smoked fewer cigarettes per day (p=0.001) compared to smokers of regular cigarettes. Despite this lower reported consumption, levels of cotinine, trans-3'-hydroxycotinine and PAHs in urine of people smoking low-tar cigarettes were not correlated with nominal tar delivery of the cigarettes they smoked. Urine concentrations of NNAL were higher in smokers of lower tar than higher tar cigarettes.
Chinese low-tar cigarettes do not deliver lower doses of nicotine and carcinogens than regular cigarettes, therefore it is unlikely that there would be any reduction in harm. CNTC's promotion of low-tar cigarettes as 'less harmful' is a violation of the World Health Organization Framework Convention on Tobacco Control, which China ratified in 2005.
低焦油卷烟在中国越来越受欢迎。中国烟草总公司(CNTC)将低焦油卷烟宣传为比普通卷烟更安全。
在中国上海共招募了 543 名男性吸烟者,他们分别吸食不同焦油含量的卷烟(15 毫克,普通卷烟;10-13 毫克低焦油卷烟;<10 毫克低焦油卷烟),完成吸烟行为问卷并提供尿样,用于分析尼古丁代谢物可铁宁和反-3'-羟基可铁宁。共随机选择了 177 个尿样用于分析多环芳烃代谢物(1-羟基芘、萘酚、羟基芴和羟基菲)和烟草特异性亚硝胺 4-(亚甲基硝氨基)-1-(3-吡啶基)-1-丁酮(NNK)代谢物,4-(亚甲基硝氨基)-1-(3-吡啶基)-1-丁醇(NNAL)和 NNAL-葡萄糖醛酸。用肌酐对数值进行标准化,以纠正尿液稀释或浓缩可能造成的扭曲。
与吸食普通卷烟的吸烟者相比,吸食低焦油卷烟的吸烟者每天吸烟量较少(p=0.001)。尽管报告的消耗量较低,但吸食低焦油卷烟的人的尿中可铁宁、反-3'-羟基可铁宁和多环芳烃的水平与他们吸食的卷烟的名义焦油输送量无关。吸食低焦油卷烟的人的 NNAL 尿液浓度高于吸食高焦油卷烟的人。
中国的低焦油卷烟并没有比普通卷烟输送更低剂量的尼古丁和致癌物,因此不太可能减少危害。CNTC 将低焦油卷烟宣传为“危害较小”,违反了中国于 2005 年批准的世界卫生组织烟草控制框架公约。