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点扫描质子束低剂量包络的实验特性。

Experimental characterization of the low-dose envelope of spot scanning proton beams.

机构信息

Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

出版信息

Phys Med Biol. 2010 Jun 21;55(12):3467-78. doi: 10.1088/0031-9155/55/12/013. Epub 2010 May 28.

Abstract

In scanned proton beam radiotherapy, multiple pencil beams are used to deliver the total dose to the target volume. Because the number of such beams can be very large, an accurate dosimetric characterization of every single pencil beam is important to provide adequate input data for the configuration of the treatment planning system. In this work, we present a method to measure the low-dose envelope of single pencil beams, known to play a meaningful role in the dose computation for scanned proton beams. We measured the low-dose proton beam envelope, which extends several centimeters outwards from the center of each single pencil beam, by acquiring lateral dose profile data, down to relative dose levels that were a factor of 10(4) lower than the central axis dose. The overall effect of the low-dose envelope on the total dose delivered by multiple pencil beams was determined by measuring the dose output as a function of field size. We determined that the low-dose envelope can be influential even for fields as large as 20 cm x 20 cm.

摘要

在扫描质子束放射治疗中,使用多个铅笔束将总剂量输送到靶体积。由于这样的光束数量可能非常多,因此对每个铅笔束进行准确的剂量学特征描述对于为治疗计划系统的配置提供足够的输入数据非常重要。在这项工作中,我们提出了一种测量单束铅笔束低剂量包络的方法,众所周知,这种方法在扫描质子束的剂量计算中起着重要作用。我们通过获取横向剂量分布数据来测量从每个单束铅笔束中心向外延伸数厘米的低剂量质子束包络,直到相对剂量水平比中心轴剂量低 10 的 4 次方。通过测量作为射野大小函数的剂量输出,确定低剂量包络对多个铅笔束输送的总剂量的整体影响。我们确定,即使对于 20 厘米 x 20 厘米的射野,低剂量包络也可能具有影响力。

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