Stemm Matthew, Beck Chad, Mannem Rajeev, Neilson John, Klein Michael J
Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States.
Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.
Ann Diagn Pathol. 2017 Jun;28:7-11. doi: 10.1016/j.anndiagpath.2016.11.004. Epub 2016 Nov 24.
Dedifferentiated chondrosarcomas (DDCS) are rare lesions, defined as tumors having a low-grade chondrosarcomatous component with an abrupt transition to a high-grade sarcoma. Although "malignant fibrous histiocytoma" (undifferentiated pleomorphic sarcoma) is the most common high grade saromatous component, many different types of sarcoma have been described. We present a case of dedifferentiated chondrosarcoma with rhabdomyosarcomatous differentiation harboring a prominent rhabdoid tumor component. To our knowledge, rhabdoid morphology in dedifferentiated chondrosarcoma has not been described in the English-language literature. The pathologic and radiologic features of this case are presented.
去分化软骨肉瘤（DDCS）是罕见的病变，定义为具有低度软骨肉瘤成分并突然转变为高度肉瘤的肿瘤。虽然“恶性纤维组织细胞瘤”（未分化多形性肉瘤）是最常见的高度肉瘤成分，但已描述了许多不同类型的肉瘤。我们报告一例具有横纹肌肉瘤分化且含有显著横纹肌样肿瘤成分的去分化软骨肉瘤病例。据我们所知，英文文献中尚未描述去分化软骨肉瘤中的横纹肌样形态。本文介绍了该病例的病理和放射学特征。
