Wang Rui-li, Qu Qiu-min, Cao Hong-mei, Zhe Xiao, Qiao Jin, Guo Feng
Department of Neurology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2010 Mar;31(3):329-32.
To study the characteristics and influencing factors of cognition on patients with Parkinson's disease (PD) in Xi'an in order to provide evidence for early recognition and treatment of cognitive impairment on PD patients.
Clinically defined PD patients from 7 hospitals in Xi'an from Jan. to Apr. 2007 were assessed with mini-mental state examination (MMSE) and Montreal cognitive assessment (MOCA) for whole cognitive function. Furthermore, Fuld object memory test (FOM) was used to assess delayed memory while rapid verbal retrieve (RVR) was used to assess language fluency. Digit span subtest was used to assess attention and building blocks was used to assess visual space function respectively.
100 PD patients were recruited, including 52 men and 48 women, from 43 to 86 years old (65.6 +/- 17.1). MMSE scores was used as the standard for Recognition, PD with cognitive impairment accounted for 16%. According to MOCA scores, with PD cognitive disturbances accounted for 83%. Ability for calculation, short-term memory, visual space function, abstract capability, attention and language fluency dysfunction were main cognitive disturbances of PD. Analysis from single factor logistic regression showed that education, age of onset and gender were closely related to the occurrence of cognitive impairment on PD patients.
Cognitive impairment was common in PD. Ability of calculation, short-term memory, visual space function, abstract capability, attention and language fluency dysfunction were main cognitive disturbances of PD. Cognitive impairment of PD was more likely to occur with low degree of education, late onset of PD, and being female.
研究西安地区帕金森病（PD）患者的认知特点及影响因素，为PD患者认知障碍的早期识别与治疗提供依据。
选取2007年1月至4月西安市7家医院临床确诊的PD患者，采用简易精神状态检查表（MMSE）和蒙特利尔认知评估量表（MOCA）评估整体认知功能。此外，运用富尔德物体记忆测验（FOM）评估延迟记忆，快速言语提取测验（RVR）评估语言流畅性。数字广度分测验用于评估注意力，积木测验用于评估视觉空间功能。
共纳入100例PD患者，其中男性52例，女性48例，年龄43至86岁（65.6±17.1）。以MMSE评分作为认知障碍的判断标准，PD合并认知障碍者占16%。以MOCA评分判断，PD合并认知功能障碍者占83%。计算能力、短期记忆、视觉空间功能、抽象能力、注意力及语言流畅性障碍是PD患者主要的认知功能障碍。单因素Logistic回归分析显示，受教育程度、发病年龄及性别与PD患者认知障碍的发生密切相关。
认知障碍在PD患者中较为常见。计算能力、短期记忆、视觉空间功能、抽象能力、注意力及语言流畅性障碍是PD患者主要的认知功能障碍。受教育程度低、发病年龄晚及女性更易发生PD认知障碍。
