Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research, University of California, San Francisco, San Francisco, CA 94158, USA.
Cell. 2010 May 28;141(5):739-45. doi: 10.1016/j.cell.2010.05.019.
Traditionally, research has been reductionist, characterizing the individual components of biological systems. But new technologies have increased the size and scope of biological data, and systems approaches have broadened the view of how these components are interconnected. Here, we discuss how quantitative mapping of genetic interactions enhances our view of biological systems, allowing their deeper interrogation across different biological scales.
传统上,研究一直是还原论的,其特点是对生物系统的各个组成部分进行描述。但是,新技术增加了生物数据的规模和范围,系统方法拓宽了这些组件如何相互连接的观点。在这里,我们讨论了遗传相互作用的定量映射如何增强我们对生物系统的认识,从而允许在不同的生物尺度上对其进行更深入的研究。