Institute of Composite and Biomedical Materials, National Research Council, Naples, Italy.
J Biomater Appl. 2011 May;25(8):795-810. doi: 10.1177/0885328209360933. Epub 2010 May 28.
Spinal disease due to intervertebral disc degeneration represents a serious medical problem which affects many people worldwide. Disc arthroplasty may be considered the future ''gold standard'' of back pain treatment, even if problems related to available disc prostheses are considered. Hence, the aim of the present study was to improve the artificial disc technology by proposing the engineering of a pilot-scale device production process for a total multi-component intervertebral disc prosthesis. The device is made up of a poly(2-hydroxyethyl methacrylate)/poly(methyl methacrylate) (PHEMA/PMMA) (80/20 w/w) semi-interpenetrating polymer network (s-IPN) composite hydrogel reinforced with poly(ethylene terephthalate) (PET) fibers as annulus/nucleus substitute, and two hydroxyapatite-reinforced polyethylene composite (HAPEX™) endplates in order to anchor the multi-component device to the vertebral bodies. Static and dynamic-mechanical characterization show appropriate mechanical behavior. An example of engineering of a suitable pilot-scale device production process is also proposed in order to manufacture custom made implants.
因椎间盘退变导致的脊柱疾病是一个严重的医学问题，影响着全球许多人。椎间盘置换术可能被视为治疗腰痛的未来“金标准”，即使考虑到现有椎间盘假体相关的问题也是如此。因此，本研究旨在通过提出一种用于全多组分椎间假体的初步规模设备生产工艺的工程设计来改进人工椎间盘技术。该设备由聚（2-羟乙基甲基丙烯酸酯）/聚（甲基丙烯酸甲酯）（PHEMA/PMMA）（80/20 w/w）半互穿聚合物网络（s-IPN）复合水凝胶增强聚对苯二甲酸乙二醇酯（PET）纤维组成，作为替代纤维环/核，以及两个羟基磷灰石增强聚乙烯复合材料（HAPEX™）终板，以便将多组分装置固定在椎体上。静态和动态力学特性显示出适当的机械行为。还提出了一个合适的初步规模设备生产工艺的工程设计示例，以便制造定制植入物。
