Tang Guoke, Zhou Bingyan, Li Feng, Wang Weiheng, Liu Yi, Wang Xing, Liu Chao, Ye Xiaojian
Department of Orthopedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Department of Spine Surgery, The Affiliated Zhuzhou Hospital of Xiangya School of Medical CSU, Zhuzhou, China.
Front Bioeng Biotechnol. 2020 Jun 30;8:745. doi: 10.3389/fbioe.2020.00745. eCollection 2020.
Intervertebral disk (IVD) degeneration is associated with most cases of cervical and lumbar spine pathologies, amongst which chronic low back pain has become the primary cause for loss of quality-adjusted life years. Biomaterials science and tissue engineering have made significant progress in the replacement, repair and regeneration of IVD tissue, wherein hydrogel has been recognized as an ideal biomaterial to promote IVD regeneration in recent years. Aspects such as ease of use, mechanical properties, regenerative capacity, and their applicability as carriers for regenerative and anti-degenerative factors determine their suitability for IVD regeneration. This current review provides an overview of naturally derived and synthetic hydrogels that are related to their clinical applications for IVD regeneration. Although each type has its own unique advantages, it rarely becomes a standard product in truly clinical practice, and a more rational design is proposed for future use of biomaterials for IVD regeneration. This review aims to provide a starting point and inspiration for future research work on development of novel biomaterials and biotechnology.
椎间盘（IVD）退变与大多数颈椎和腰椎疾病相关，其中慢性下腰痛已成为导致质量调整生命年损失的主要原因。生物材料科学和组织工程在IVD组织的置换、修复和再生方面取得了重大进展，近年来水凝胶已被公认为促进IVD再生的理想生物材料。诸如易用性、力学性能、再生能力以及它们作为再生和抗退变因子载体的适用性等方面决定了它们对IVD再生的适用性。本综述概述了与IVD再生临床应用相关的天然衍生水凝胶和合成水凝胶。尽管每种类型都有其独特优势，但在真正的临床实践中很少成为标准产品，并且针对未来用于IVD再生的生物材料提出了更合理的设计。本综述旨在为新型生物材料和生物技术开发的未来研究工作提供一个起点和灵感。
