Gloria Antonio, Causa Filippo, De Santis Roberto, Netti Paolo Antonio, Ambrosio Luigi
Institute of Composite and Biomedical Materials, National Research Council and Interdisciplinary Research Centre in Biomaterials, University of Naples Federico II, P. Tecchio 80, 80125 Naples, Italy.
J Mater Sci Mater Med. 2007 Nov;18(11):2159-65. doi: 10.1007/s10856-007-3003-z. Epub 2007 Jul 10.
Over the past years, a tremendous effort has been made to develop an intervertebral disc (IVD) prosthesis with suitable biological, mechanical and transport properties. However, it has been frequently reported that current prostheses undergo failure mainly due to the mismatch between the mechanical properties of the conventional device and the spine segment to be replaced. The aim of the present work was to develop a poly(2-hydroxyethyl methacrylate)/poly(methyl methacrylate) (PHEMA/PMMA) (80/20 w/w) semi-interpenetrating polymer network (s-IPN) composite hydrogel reinforced with poly(ethylene terephthalate) (PET) fibres, and to investigate the static and dynamic mechanical properties. Filament winding and moulding technologies were employed to obtain the composite IVD prostheses with the unique complex structure that is peculiar to the natural IVD. The compressive properties analysis showed the typical J-shaped stress-strain curve which is displayed by natural IVDs. Compressive modulus varied from 84 to 120 MPa, as a function of the strain rate, and stress was higher than 10 MPa. These values are in the range of those of the natural lumbar IVDs. No failure of the prostheses has occurred during fatigue test performed for ten million cycles in physiological solution. Dynamic mechanical tests have confirmed the composite IVD prostheses exhibited appropriate viscoelastic properties.
在过去几年中，人们付出了巨大努力来开发一种具有合适生物学、力学和传输特性的椎间盘（IVD）假体。然而，经常有报道称，目前的假体出现故障主要是由于传统装置的力学性能与待置换的脊柱节段不匹配。本研究的目的是开发一种用聚对苯二甲酸乙二酯（PET）纤维增强的聚（甲基丙烯酸2-羟乙酯）/聚（甲基丙烯酸甲酯）（PHEMA/PMMA）（80/20 w/w）半互穿聚合物网络（s-IPN）复合水凝胶，并研究其静态和动态力学性能。采用纤维缠绕和模塑技术来获得具有天然IVD特有的独特复杂结构的复合IVD假体。压缩性能分析显示出天然IVD呈现的典型J形应力-应变曲线。压缩模量根据应变率的不同在84至120 MPa之间变化，应力高于10 MPa。这些值在天然腰椎IVD的范围内。在生理溶液中进行的一千万次循环疲劳试验期间，假体未出现故障。动态力学测试证实复合IVD假体表现出适当的粘弹性特性。
