Zuckerman M A, Wood J, Chakraverty P, Taylor J, Heath A B, Oxford J S
Department of Medical Microbiology, London Hospital Medical College, Whitechapel, England.
J Med Virol. 1991 Feb;33(2):133-7. doi: 10.1002/jmv.1890330213.
A study of the immunogenicity of the inactivated trivalent subunit influenza vaccine for the 1989/90 season was performed in what proved to be an influenza epidemic year. One hundred student volunteers at The London Hospital Medical College participated in the study and the findings indicated that there was an excellent serological match between the epidemic strain of influenza A (H3N2) and the vaccine strain. Before vaccination, the geometric mean titre (GMT) to A/England/308/89, a representative H3N2 epidemic strain in the United Kingdom from the 1989/90 season, was 46. Post-vaccination the antibody levels rose and 99% of vaccinees had HI titres of greater than or equal to 40, the GMT being 131. The serological responses were also investigated against other circulating influenza A (H3N2 and H1N1) and B strains. Preliminary results of an evaluation of the rapidity of the immune response showed that in three of six subjects rises in HI antibody appeared within two days of vaccination.
在一个后来被证明是流感流行的年份里，对1989/90年度的三价灭活亚单位流感疫苗的免疫原性进行了一项研究。伦敦医院医学院的100名学生志愿者参与了该研究，研究结果表明，甲型（H3N2）流感流行毒株与疫苗毒株之间存在良好的血清学匹配。接种疫苗前，针对1989/90年度英国一种具有代表性的H3N2流行毒株A/England/308/89的几何平均滴度（GMT）为46。接种疫苗后，抗体水平上升，99%的接种者血凝抑制（HI）滴度大于或等于40，GMT为131。还针对其他流行的甲型（H3N2和H1N1）和乙型流感毒株研究了血清学反应。一项关于免疫反应速度评估的初步结果显示，在六名受试者中有三名在接种疫苗后两天内出现了HI抗体升高。
