Rasmussen Lucas Trevizani, Labio Roger William de, Gatti Luciano Lobo, Silva Luiz Carlos da, Queiroz Valdeir Fagundes de, Smith Marília de Arruda Cardoso, Payão Spencer Luiz Marques
Universidade do Sagrado Coração, Bauru, SP, Brasil.
Mem Inst Oswaldo Cruz. 2010 May;105(3):326-30. doi: 10.1590/s0074-02762010000300015.
Helicobacter pylori is an important human pathogen that causes chronic gastritis and is associated with the development of peptic ulcer disease and gastric malignancies. The oral cavity has been implicated as a potential H. pylori reservoir and may therefore be involved in the reinfection of the stomach, which can sometimes occur following treatment of an H. pylori infection. The objectives of this paper were (i) to determine the presence of H. pylori in the oral cavity and (ii) to examine the relationship between oral H. pylori and subsequent gastritis. Gastric biopsies, saliva samples and dental plaques were obtained from 78 dyspeptic adults. DNA was extracted and evaluated for the presence of H. pylori using polymerase chain reaction and Southern blotting methods. Persons with gastritis were frequently positive for H. pylori in their stomachs (p < 0.0001) and there was a statistically significant correlation between the presence of H. pylori in gastric biopsies and the oral cavity (p < 0.0001). Our results suggest a relationship between gastric infection and the presence of this bacterium in the oral cavity. Despite this, H. pylori were present in the oral cavity with variable distribution between saliva and dental plaques, suggesting the existence of a reservoir for the species and a potential association with gastric reinfection.
幽门螺杆菌是一种重要的人类病原体，可导致慢性胃炎，并与消化性溃疡疾病及胃部恶性肿瘤的发生有关。口腔被认为是幽门螺杆菌的一个潜在储存库，因此可能参与胃部的再感染，这种情况有时会在幽门螺杆菌感染治疗后发生。本文的目的是：（i）确定口腔中幽门螺杆菌的存在情况；（ii）研究口腔幽门螺杆菌与后续胃炎之间的关系。从78名消化不良的成年人身上获取了胃活检组织、唾液样本和牙菌斑。提取DNA，并使用聚合酶链反应和Southern印迹法评估幽门螺杆菌的存在情况。患有胃炎的人其胃部幽门螺杆菌检测结果常呈阳性（p < 0.0001），胃活检组织和口腔中幽门螺杆菌的存在之间存在统计学上的显著相关性（p < 0.0001）。我们的结果表明胃部感染与该细菌在口腔中的存在之间存在关联。尽管如此，幽门螺杆菌在口腔中的分布在唾液和牙菌斑之间存在差异，这表明该菌种存在一个储存库，并且可能与胃部再感染有关。
