Department of Surgery, State University of New York-Buffalo, Kaleida Health, Buffalo General Hospital, Buffalo, New York 14203, USA.
J Surg Oncol. 2010 Jun 15;101(8):706-12. doi: 10.1002/jso.21505.
Patients with ulcerative colitis (UC) are at an increased risk for the development of colorectal cancer (CRC). Unlike sporadic CRC, the cancer in UC patients arises from a focal or multifocal dysplastic mucosa in areas of inflammation. The clinical features of UC-associated cancer are similar to those found in patients with hereditary non-polyposis colorectal cancer. As with other varieties of CRC, UC-associated cancer exhibits a variety of genetic and molecular changes/abnormalities. These abnormalities are however clustered in areas of mucosae with histological abnormalities. The magnitude and timing of these changes are however significantly different. Surveillance and identification of patients at risk for cancer are a challenging problem.
溃疡性结肠炎（UC）患者发生结直肠癌（CRC）的风险增加。与散发性 CRC 不同，UC 患者的癌症源自炎症区域的局灶性或多灶性发育异常黏膜。UC 相关癌症的临床特征与遗传性非息肉病性结直肠癌患者相似。与其他类型的 CRC 一样，UC 相关的癌症表现出多种遗传和分子变化/异常。然而，这些异常集中在具有组织学异常的黏膜区域。这些变化的程度和时间有很大的不同。监测和识别有癌症风险的患者是一个具有挑战性的问题。
