Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
J Korean Med Sci. 2010 Jun;25(6):924-9. doi: 10.3346/jkms.2010.25.6.924. Epub 2010 May 24.
We evaluated the recent trend in the incidence of premalignant and malignant skin lesions between 1991 and 2006. Among 571,057 newly registered dermatology out-patients from our 8 affiliated university hospitals, 2,598 were diagnosed with a premalignant (899, 0.16%) or malignant skin lesions (1,699, 0.30%). Of 899 premalignant cases, 71.2% were actinic keratosis (AK), and 24.6% were Bowen's disease. Of 1,699 malignant cases, 46.2% were basal cell carcinoma, followed by squamous cell carcinoma (19.1%) and melanoma (7.1%). This 16-yr survey was divided equally into two time periods to compare the incidence of premalignant and malignant skin lesions at different time settings. Between 1991 and 1998, the incidence of cutaneous premalignancy was 0.10% which doubled during 1999-2006. For cutaneous malignancy, the incidence was 0.25% during 1991-1998 and 0.34% in 1999-2006. Incidence of AK among the new outpatients was 0.07% in 1991-1998 which staggered up to 0.15% in 1999-2006. These findings show an increase of both premalignant and malignant skin lesions, AK in particular in the dermatology outpatient-based incidence.
我们评估了 1991 年至 2006 年间癌前和恶性皮肤病变的发病率变化趋势。在我们 8 所附属医院的 571,057 名新登记的皮肤科门诊患者中，有 2,598 名被诊断患有癌前病变（899 例，0.16%）或恶性皮肤病变（1,699 例，0.30%）。在 899 例癌前病变中，71.2%为光化性角化病（AK），24.6%为 Bowen 病。在 1,699 例恶性病例中，46.2%为基底细胞癌，其次为鳞状细胞癌（19.1%）和黑色素瘤（7.1%）。这项 16 年的调查分为两个相等的时间段，以比较不同时间设置下癌前和恶性皮肤病变的发病率。1991 年至 1998 年期间，皮肤癌前病变的发病率为 0.10%，而在 1999 年至 2006 年期间则翻了一番。对于皮肤恶性肿瘤，1991 年至 1998 年的发病率为 0.25%，1999 年至 2006 年的发病率为 0.34%。1991 年至 1998 年期间，新门诊患者中 AK 的发病率为 0.07%，而在 1999 年至 2006 年期间则上升至 0.15%。这些发现表明，癌前和恶性皮肤病变，尤其是皮肤科门诊患者中的 AK 发病率都有所增加。
