Miyamae T
Am J Vet Res. 1978 Mar;39(3):503-4.
A serial 34-chicken pancreas passage of avian encephalomyelitis virus by oral administration was successful. Oral inoculation test with 4 passaged viruses showed rapid infection of the duodenal wall and unchangeable infection of pancreas diminishing the viral invasiveness to other organs. The passaged virus caused neither detectable viremia nor clinical avian encephalomyelitis signs and produced neutralizing antibody of high titers.
通过口服途径对禽脑脊髓炎病毒进行连续34代鸡胰腺传代获得成功。对4代传代病毒进行口服接种试验表明，十二指肠壁感染迅速，胰腺感染无变化，病毒对其他器官的侵袭性减弱。传代病毒既未引起可检测到的病毒血症，也未出现临床禽脑脊髓炎症状，并产生了高滴度的中和抗体。
