Greco Timothy M, Elenitsas Rosalie
Division of Facial Plastic and Reconstructive Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
J Drugs Dermatol. 2010 Apr;9(4):399-404.
To describe a technique for surgical correction of a prominent nasolabial fold (NLF) and use of the excised fold to assess the histology and localization of injected hyaluronic acid (HA) fillers.
Surgical correction was achieved by direct excision of the NLF, followed by advancement of the nasolabial fat compartment into the nasolabial crease. Excised tissue samples were injected with HA fillers (Restylane, Perlane, or layered Restylane/ Perlane), sectioned, and treated with histological stains.
Surgical correction of NLF resulted in highly satisfactory results. HA localized primarily in the lower reticular dermis and subcutis of the excised NLF. Localization appeared similar regardless of the HA product employed.
Direct excision of the NLF with advancement of the nasolabial fat compartment is a successful treatment for patients with deep NLF. HA injected into the excised tissue localized near the site of injection, emphasizing the importance of proper placement of HA fillers during soft tissue augmentation.
描述一种用于手术矫正明显鼻唇沟（NLF）的技术，并利用切除的鼻唇沟来评估注射用透明质酸（HA）填充剂的组织学和定位情况。
通过直接切除鼻唇沟，随后将鼻唇脂肪间隔推进至鼻唇沟来实现手术矫正。将切除的组织样本注射HA填充剂（瑞蓝、乔雅登或分层注射瑞蓝/乔雅登），切片，并进行组织学染色处理。
鼻唇沟的手术矫正取得了非常满意的效果。HA主要定位于切除的鼻唇沟的下部网状真皮和皮下组织。无论使用何种HA产品，定位情况似乎相似。
直接切除鼻唇沟并推进鼻唇脂肪间隔对于鼻唇沟较深的患者是一种成功的治疗方法。注射到切除组织中的HA定位于注射部位附近，强调了在软组织填充过程中正确放置HA填充剂的重要性。
