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Emervel法国调查:一项对1822例使用新型透明质酸填充剂进行面部年轻化治疗的患者的前瞻性实际应用描述性研究。

The Emervel French survey: a prospective real-practice descriptive study of 1,822 patients treated for facial rejuvenation with a new hyaluronic acid filler.

作者信息

Farhi David, Trevidic Patrick, Kestemont Philippe, Boineau Dominique, Cartier Hugues, Bodokh Isaac, Brun Patrick, Ascher Benjamin, Savary Jacques

机构信息

Dermatology Clinic, 75013 Paris, France.

出版信息

J Drugs Dermatol. 2013 May;12(5):e88-93.

Abstract

BACKGROUND

Emervel consists of a range of 5 hyaluronic acid (HA) fillers (Touch, Classic, Lips, Deep, and Volume), with a fixed HA concentration (20 mg/mL), and various degrees of cross-linking and calibration.

OBJECTIVES

To describe the current use of Emervel fillers in France.

METHODS

Prospective multicenter, cross-sectional, real-practice, descriptive survey, including 1,822 patients injected with Emervel fillers for face rejuvenation by 58 French physicians between September 2010 and July 2011. The injection modalities were left to the respective physician's discretion.

RESULTS

The physicians were dermatologists (52.3%), surgeons (43.8%), or general practitioners (14.1%). Nasolabial folds (NLF) with a mean severity 2.4 were mainly injected with Emervel Deep (51.0%) and Emervel Classic (36.0%) (mean volume: 1.0 mL), and primarily with the linear retrograde (LR) technique (89.3%). Marionette lines (ML), with a mean severity 2.6 were mainly injected with Emervel Deep (52.5%) and Emervel Classic (34.6%) (mean volume: 0.8 mL), and mainly with the LR technique (79.5%). More than 90% of patients had scores of 0 or 1 for erythema, bruising, edema, and pain. No serious adverse events were reported up to 15 months after the injection.

CONCLUSION

These data could contribute to upcoming international consensus on optimal injection modalities of the Emervel range of HA fillers.

摘要

背景

伊婉(Emervel)由一系列5种透明质酸(HA)填充剂组成(Touch、Classic、Lips、Deep和Volume),其透明质酸浓度固定为20mg/mL,并具有不同程度的交联和校准。

目的

描述伊婉填充剂在法国的当前使用情况。

方法

前瞻性多中心、横断面、实际操作的描述性调查,纳入2010年9月至2011年7月间由58名法国医生为1822例患者注射伊婉填充剂进行面部年轻化治疗的情况。注射方式由各医生自行决定。

结果

医生包括皮肤科医生(52.3%)、外科医生(43.8%)或全科医生(14.1%)。平均严重程度为2.4的鼻唇沟主要注射伊婉Deep(51.0%)和伊婉Classic(36.0%)(平均剂量:1.0mL),主要采用线性逆行(LR)技术(89.3%)。平均严重程度为2.6的木偶纹主要注射伊婉Deep(52.5%)和伊婉Classic(34.6%)(平均剂量:0.8mL),主要采用LR技术(79.5%)。超过90%的患者在红斑、瘀斑、水肿和疼痛方面的评分为0或1分。注射后长达15个月未报告严重不良事件。

结论

这些数据可为即将达成的关于伊婉系列透明质酸填充剂最佳注射方式的国际共识做出贡献。

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