Geriatric Unit and Laboratory of Movement Analysis, Geriatric-Rehabilitation Department, University Hospital of Parma, Parma, Italy.
Aging Male. 2010 Dec;13(4):215-32. doi: 10.3109/13685538.2010.487551. Epub 2010 Jun 1.
Vitamin D is a group of lipophilic hormones with pleiotropic actions. It has been traditionally related to bone metabolism, although several studies in the last decade have suggested its role in muscle strength and falls, cardiovascular and neurological diseases, insulin-resistance and diabetes, malignancies, autoimmune diseases and infections. Vitamin D appears to be a hormone with several actions and is fundamental for many biological systems including bone, skeletal muscle, brain and heart. The estimated worldwide prevalence of vitamin D deficiency of 50% in elderly subjects underlines the importance of vitamin D deficiency for public health. In this review, we will describe changes in vitamin D levels with age in both sexes, cut off values to define Vitamin D status, the impact of vitamin D deficiency in age-related disease and finally different therapeutic options available to treat Vitamin D deficiency in older populations.
维生素 D 是一类脂溶性激素，具有多种作用。传统上，它与骨骼代谢有关，尽管过去十年的多项研究表明它在肌肉力量和跌倒、心血管和神经疾病、胰岛素抵抗和糖尿病、恶性肿瘤、自身免疫性疾病和感染方面发挥着作用。维生素 D 似乎是一种具有多种作用的激素，对包括骨骼、骨骼肌、大脑和心脏在内的许多生物系统都至关重要。据估计，全世界 50%的老年人群存在维生素 D 缺乏，这凸显了维生素 D 缺乏对公共健康的重要性。在这篇综述中，我们将描述两性中维生素 D 水平随年龄的变化、定义维生素 D 状态的截止值、维生素 D 缺乏对与年龄相关疾病的影响，以及最后治疗老年人群维生素 D 缺乏的不同治疗选择。
