Bacchetta J, Ranchin B, Dubourg L, Cochat P
David Geffen School of Medicine, UCLA, Los Angeles, USA.
Arch Pediatr. 2010 Dec;17(12):1687-95. doi: 10.1016/j.arcped.2010.09.003. Epub 2010 Oct 14.
There is a recent renewed interest in vitamin D metabolism and pathophysiology, due to its recent description as a hormone with a positive impact on global health rather than a strictly bone hormone: vitamin D could be a protective factor against infection, autoimmunity, cardiovascular morbidity, and cancer. By contrast, vitamin D deficiency appears to be increasingly frequent worldwide. We propose a review of these new aspects of vitamin D metabolism, with a focus on vitamin D status in a local pediatric cohort. There is an urgent need for revisiting current guidelines on vitamin D supplementation and for closely monitoring serum vitamin D in children with chronic diseases, i.e., at greater risk of cardiovascular impairment, bone morbidity, infectious disease, and acute inflammation.
由于维生素D最近被描述为一种对全球健康有积极影响的激素，而非仅仅是一种严格意义上的骨激素，近期人们对其代谢和病理生理学重新产生了兴趣：维生素D可能是预防感染、自身免疫、心血管疾病和癌症的保护因素。相比之下，维生素D缺乏在全球范围内似乎越来越普遍。我们建议对维生素D代谢的这些新方面进行综述，重点关注当地儿科队列中的维生素D状况。迫切需要重新审视当前关于维生素D补充的指南，并密切监测患有慢性疾病的儿童的血清维生素D水平，即那些有更高心血管损害、骨骼疾病、传染病和急性炎症风险的儿童。
