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异氟烷通过抑制海马体中脑源性神经营养因子诱导短暂性顺行性遗忘。

Isoflurane Induces Transient Anterograde Amnesia through Suppression of Brain-Derived Neurotrophic Factor in Hippocampus.

作者信息

Cho Han-Jin, Sung Yun-Hee, Lee Seung-Hwan, Chung Jun-Young, Kang Jong-Man, Yi Jae-Woo

机构信息

Department of Emergency Medicine, Korea University College of Medicine, Ansan Hospital, Ansan, Korea.

出版信息

J Korean Neurosurg Soc. 2013 Mar;53(3):139-44. doi: 10.3340/jkns.2013.53.3.139. Epub 2013 Mar 31.

DOI:10.3340/jkns.2013.53.3.139
PMID:23634262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3638265/
Abstract

OBJECTIVE

Transient anterograde amnesia is occasionally observed in a number of conditions, including migraine, focal ischemia, venous flow abnormalities, and after general anesthesia. The inhalation anesthetic, isoflurane, is known to induce transient anterograde amnesia. We examined the involvement of brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B (TrkB) in the underlying mechanisms of the isoflurane-induced transient anterograde amnesia.

METHODS

Adult male Sprague-Dawley rats were divided into three groups : the control group, the 10 minutes after recovery from isoflurane anesthesia group, and the 2 hours after recovery from isoflurane anesthesia group (n=8 in each group). The rats in the isoflurane-exposed groups were anesthetized with 1.2% isoflurane in 75% nitrous oxide and 25% oxygen for 2 hours in a Plexiglas anesthetizing chamber. Short-term memory was determined using the step-down avoidance task. BDNF and TrkB expressions in the hippocampus were evaluated by immunofluorescence staining and western blot analysis.

RESULTS

Latency in the step-down avoidance task was decreased 10 minutes after recovery from isoflurane anesthesia, whereas it recovered to the control level 2 hours after isoflurane anesthesia. The expressions of BDNF and TrkB in the hippocampus were decreased immediately after isoflurane anesthesia but were increased 2 hours after isoflurane anesthesia.

CONCLUSION

In this study, isoflurane anesthesia induced transient anterograde amnesia, and the expressions of BDNF and TrkB in the hippocampus might be involved in the underlying mechanisms of this transient anterograde amnesia.

摘要

目的

短暂性顺行性遗忘在多种情况下偶有发生，包括偏头痛、局灶性缺血、静脉血流异常以及全身麻醉后。吸入性麻醉剂异氟烷已知可诱发短暂性顺行性遗忘。我们研究了脑源性神经营养因子（BDNF）及其受体酪氨酸激酶B（TrkB）在异氟烷诱发短暂性顺行性遗忘潜在机制中的作用。

方法

成年雄性Sprague-Dawley大鼠分为三组：对照组、异氟烷麻醉苏醒后10分钟组和异氟烷麻醉苏醒后2小时组（每组n = 8）。异氟烷暴露组的大鼠在有机玻璃麻醉箱中用1.2%异氟烷、75%氧化亚氮和25%氧气麻醉2小时。使用避暗任务测定短期记忆。通过免疫荧光染色和蛋白质印迹分析评估海马中BDNF和TrkB的表达。

结果

异氟烷麻醉苏醒后10分钟，避暗任务中的潜伏期缩短，而异氟烷麻醉后2小时恢复到对照水平。异氟烷麻醉后海马中BDNF和TrkB的表达立即降低，但异氟烷麻醉后2小时升高。

结论

在本研究中，异氟烷麻醉诱发了短暂性顺行性遗忘，海马中BDNF和TrkB的表达可能参与了这种短暂性顺行性遗忘的潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427b/3638265/03a5f36eb200/jkns-53-139-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427b/3638265/1f0bb25dbe2f/jkns-53-139-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427b/3638265/ead86cc62391/jkns-53-139-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427b/3638265/03a5f36eb200/jkns-53-139-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427b/3638265/1f0bb25dbe2f/jkns-53-139-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427b/3638265/ead86cc62391/jkns-53-139-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/427b/3638265/03a5f36eb200/jkns-53-139-g003.jpg

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