Department of Ophthalmology, University of Campinas, Campinas, Rua Bahia 1087, São Paulo, Brazil.
Br J Ophthalmol. 2010 Oct;94(10):1291-4. doi: 10.1136/bjo.2009.167569. Epub 2010 Jun 1.
To compare the 24 h intraocular pressure (IOP), blood pressure (BP), and perfusion pressure (PP) of primary open-angle glaucoma (POAG) patients and healthy individuals.
24 healthy individuals and 29 POAG patients underwent IOP and BP measurements every 2 h, starting at 08:00 until 06:00 of the next morning. IOP measurements were made by a masked observer with a Goldmann tonometer at the slit-lamp from 08:00 to 22:00 and with the Perkins tonometer in supine position from 24:00 to 06:00. Systolic and diastolic BP (SBP and DBP) measurements were performed with an automated device.
Mean IOPs in POAG patients were significantly higher at all time intervals (p<0.001). The mean SBP was significantly higher in POAG patients from 04:00 to 10:00, and also at 14:00 and 18:00 (p<0.05). In POAG patients, the mean DBP was significantly higher at 08:00 and 10:00, but was significantly lower at 04:00 (p<0.05). In POAG patients, the mean systolic perfusion pressure (SPP) was significantly higher at 08:00 and 10:00 (p<0.01), whereas the mean diastolic perfusion pressure (DPP) was significantly lower from 24:00 to 06:00 (p<0.05).
Although higher SPPs are observed in POAG patients during the morning, lower DPPs are found during the night.
比较原发性开角型青光眼（POAG）患者和健康个体的 24 小时眼压（IOP）、血压（BP）和灌注压（PP）。
29 例 POAG 患者和 24 名健康个体接受了每 2 小时一次的 IOP 和 BP 测量，从早上 08:00 持续到第二天早上 06:00。IOP 测量由一名戴眼罩的观察者使用 Goldmann 眼压计在裂隙灯显微镜下进行，从 08:00 到 22:00，以及使用 Perkins 眼压计在仰卧位进行，从 24:00 到 06:00。SBP 和 DBP 测量使用自动设备进行。
POAG 患者的平均 IOP 在所有时间间隔均显著升高（p<0.001）。POAG 患者的平均 SBP 从 04:00 到 10:00、14:00 和 18:00 显著升高（p<0.05）。POAG 患者的平均 DBP 在 08:00 和 10:00 显著升高，但在 04:00 显著降低（p<0.05）。POAG 患者的平均收缩期灌注压（SPP）在 08:00 和 10:00 显著升高（p<0.01），而平均舒张期灌注压（DPP）从 24:00 到 06:00 显著降低（p<0.05）。
虽然 POAG 患者在早上观察到较高的 SPP，但在夜间发现较低的 DPP。
