Center for Translational Medicine in Women's Health, University of Washington, Seattle, WA 98109, USA.
J Clin Oncol. 2010 Oct 10;28(29):4531-8. doi: 10.1200/JCO.2009.27.2146. Epub 2010 Jun 1.
Innate and adaptive immune system cells play a major role in regulating the growth of cancer. Although it is commonly thought that an immune response localized to the tumor will inhibit cancer growth, it is clear that some types of inflammation induced in a tumor may also lead to cancer proliferation, invasion, and dissemination. Recent evidence suggests, however, that some patients with cancer can mount an antitumor immune response that has the potential to control or eliminate cancer. Indeed, a so-called "immune response" signature has been described in malignancy that is associated with improved outcomes in several tumor types. Moreover, the presence of specific subsets of T cells, which have the capability to penetrate tumor stroma and infiltrate deep into the parenchyma, identifies patients with an improved prognosis. Immune-based therapies have the potential to modulate the tumor microenvironment by eliciting immune system cells that will initiate acute inflammation that leads to tissue destruction.
先天和适应性免疫系统细胞在调节癌症生长方面发挥着重要作用。尽管人们普遍认为局部肿瘤的免疫反应将抑制癌症生长，但很明显，肿瘤中诱导的某些类型的炎症也可能导致癌症增殖、侵袭和扩散。然而，最近的证据表明，一些癌症患者可以产生抗肿瘤免疫反应，从而有可能控制或消除癌症。事实上，在几种肿瘤类型中，已经描述了一种与改善预后相关的所谓“免疫反应”特征。此外，具有穿透肿瘤基质并深入实质能力的特定 T 细胞亚群的存在可识别出预后改善的患者。免疫疗法有可能通过引发免疫系统细胞引发急性炎症导致组织破坏来调节肿瘤微环境。
