University of Health Sciences, Lahore, Pakistan.
Caries Res. 2010;44(3):272-6. doi: 10.1159/000314675. Epub 2010 May 27.
Oral candidiasis is one of the most common opportunistic oral fungal infections. Oral candidal carriage in schoolchildren is a subject of increasing interest worldwide and has recently been associated with increased caries incidence in children.
This study was carried out to identify association between oral candidal carriage in children and dental caries.
One hundred subjects with an age range between 6 and 12 years were included in this study. The subjects were distributed equally into two groups, i.e., study (caries-positive) and control (caries-free) groups. Oral hygiene index and DMFT/dmft scores were recorded for each subject. Sampling for Candida was carried out using intraoral swabs and concentrated oral rinse. Sabouraud dextrose agar containing 0.1 mg/ml of chloramphenicol was used as the primary culture medium. Candida was identified by employing API-20C AUX and germ tube formation tests.
The subjects in the caries-positive group showed a high frequency of oral candidal carriage compared to the caries-free subjects and the results were statistically very significant (p < 0.01). The odds ratio was 67.37, implying a high caries risk with positive oral candidal carriage (95% CI 14-323).
The findings of this study underscore the possible association of Candida with dental caries.
The occurrence of dental caries in children with mixed dentition is positively correlated with the frequency of oral candidal carriage.
口腔念珠菌病是最常见的机会性口腔真菌感染之一。儿童口腔念珠菌携带情况是全球日益关注的课题，最近与儿童龋齿发病率增加有关。
本研究旨在确定儿童口腔念珠菌携带与龋齿之间的关联。
本研究纳入了 100 名年龄在 6 至 12 岁之间的受试者。将受试者平均分为两组，即研究组（龋齿阳性）和对照组（无龋齿）。为每位受试者记录口腔卫生指数和 DMFT/dmft 评分。使用口腔内拭子和浓缩口腔冲洗液进行念珠菌采样。使用含 0.1mg/ml 氯霉素的沙氏葡萄糖琼脂作为初级培养基。通过 API-20C AUX 和芽管形成试验鉴定念珠菌。
与无龋齿组相比，龋齿阳性组的受试者口腔念珠菌携带率更高，结果具有统计学意义（p < 0.01）。优势比为 67.37，表明阳性口腔念珠菌携带与高龋齿风险相关（95%CI 14-323）。
本研究结果强调了念珠菌与龋齿之间可能存在关联。
混合牙列儿童的龋齿发生与口腔念珠菌携带频率呈正相关。
