Pu Xinyao, Fang Bing, Wu Jianmin, Zhao Zhi, Liu Yue, Li Jingyu, Gao Haina, Wang Ran, Zhang Ming
School of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Foods. 2024 Dec 19;13(24):4118. doi: 10.3390/foods13244118.
In the pathogenesis of dental caries, () plays a central role. can produce extracellular polysaccharides, which can help the bacteria form biofilms on the tooth surface, create a stable living environment, and hinder the removal of bacteria by natural defense substances in the oral cavity such as saliva. Meanwhile, the oral microbiota and dietary habits exert long-term influences on its development. This study, employing the BALB/c mouse model, explored the effects of L9 on dental caries. In the experiment, mice underwent the inoculation and were subsequently treated with L9 or K12 for 28 consecutive days. The results showed that L9 significantly ameliorated early enamel caries, and both L9 and K12 cooperatively downregulated the expressions of critical cariogenic factors, effectively suppressing the initial adhesion of and the formation of dental plaques. L9 reshaped the oral microbiota of caries-affected mice, selectively reducing pathogens abundances and augmenting abundances of probiotics such as Lactobacillaceae and . This study offers a strategic approach for the management of dental caries, highlighting the potential of these probiotics in the field of oral health.
在龋齿的发病机制中，（）起着核心作用。（）能产生细胞外多糖，有助于细菌在牙齿表面形成生物膜，创造稳定的生存环境，并阻碍口腔中唾液等天然防御物质清除细菌。同时，口腔微生物群和饮食习惯对其发展产生长期影响。本研究采用BALB/c小鼠模型，探讨了L9对龋齿的影响。在实验中，小鼠接受（）接种，随后连续28天用L9或K12处理。结果表明，L9显著改善早期釉质龋，L9和K12协同下调关键致龋因子的表达，有效抑制（）的初始黏附及牙菌斑的形成。L9重塑了患龋小鼠的口腔微生物群，选择性降低病原体丰度，增加乳酸菌科和（）等益生菌的丰度。本研究为龋齿的管理提供了一种策略方法，突出了这些益生菌在口腔健康领域的潜力。
