Effects of L9 on Oral Microbiota and Cariogenic Factors in -Infected Mice.

In the pathogenesis of dental caries, () plays a central role. can produce extracellular polysaccharides, which can help the bacteria form biofilms on the tooth surface, create a stable living environment, and hinder the removal of bacteria by natural defense substances in the oral cavity such as saliva. Meanwhile, the oral microbiota and dietary habits exert long-term influences on its development. This study, employing the BALB/c mouse model, explored the effects of L9 on dental caries. In the experiment, mice underwent the inoculation and were subsequently treated with L9 or K12 for 28 consecutive days. The results showed that L9 significantly ameliorated early enamel caries, and both L9 and K12 cooperatively downregulated the expressions of critical cariogenic factors, effectively suppressing the initial adhesion of and the formation of dental plaques. L9 reshaped the oral microbiota of caries-affected mice, selectively reducing pathogens abundances and augmenting abundances of probiotics such as Lactobacillaceae and . This study offers a strategic approach for the management of dental caries, highlighting the potential of these probiotics in the field of oral health.