Shinohara T, Sasaki H, Morimatsu Y, Ishihara K
Appl Neurophysiol. 1976;39(3-4):251-6. doi: 10.1159/000102500.
28 autopsy cases were investigated in which the thalamus was impaired in early life, i.e. prenatal, perinatal, and postnatal (under 1 year of age). The thalamus is vulnerable to brain damage in the perinatal and early postnatal period. Lesions in the thalamus are severe in the DM, PL and VPL, and moderate in the VL and pulvinar thalamus. The anterior nuclei and center median show little change. Many of the cases with athetoid movements have complicated thalamic lesions in addition to those of the basal ganglia. In one patient who showed athetosis as a sequela of encephalitis japonica, the VL and PL in the thalamus were involved severely; in contrast the basal ganglia revealed very slight changes.
对28例丘脑在生命早期即产前、围产期及产后（1岁以下）受损的尸检病例进行了研究。丘脑在围产期和出生后早期易受脑损伤。丘脑病变在背内侧核（DM）、丘脑前核（PL）和丘脑腹后外侧核（VPL）较为严重，在丘脑腹外侧核（VL）和丘脑枕较轻。前核和中央中核变化较小。许多有手足徐动症的病例除基底神经节病变外，还伴有复杂的丘脑病变。在1例因日本脑炎后遗症出现手足徐动症的患者中，丘脑的VL和PL严重受累；相比之下，基底神经节仅有非常轻微的变化。
