Department of Medicine for Motor Organ, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Int Orthop. 2011 Jun;35(6):831-8. doi: 10.1007/s00264-010-1045-1. Epub 2010 Jun 2.
An enhanced expression of the inflammatory mediators in the perimeniscal synovium in knee osteoarthritis (OA) has been suggested to contribute to progressive cartilage degeneration. However, whether the expression levels of these molecules correlated with the severity of OA still remained unclear. Medial perimeniscal synovial samples were obtained from 23 patients with Kellgren-Lawrence (K/L) grades 2 to 4 of medial knee OA. Immunohistochemical analysis of the synovium revealed that the MMP-1, COX-2 and IL-1β expression of the patients with K/L 4 to be significantly reduced in comparison to those with either K/L 2 or 3, while the TGF-β expression showed the opposite. The synovial expression of MMP-1 and IL-1β showed a significant negative correlation with the severity of OA, while that of TGF-β again showed the opposite. In conclusion, although synovial inflammation remained active, the MMP-1, COX-2 and IL-1β expression in synovium decreased depending upon the severity of OA, while the TGF-β expression increased.
有研究表明，膝关节骨关节炎（OA）半月板滑膜中的炎症介质表达增强，可能导致进行性软骨退变。然而，这些分子的表达水平与 OA 的严重程度是否相关仍不清楚。本研究从 23 例 KL 分级 2 至 4 级的内侧膝关节 OA 患者中获取内侧半月板滑膜样本。滑膜的免疫组化分析显示，KL4 患者的 MMP-1、COX-2 和 IL-1β表达明显低于 KL2 或 3 患者，而 TGF-β 表达则相反。MMP-1 和 IL-1β 的滑膜表达与 OA 的严重程度呈显著负相关，而 TGF-β 则相反。总之，尽管滑膜炎症仍然活跃，但随着 OA 严重程度的增加，滑膜中 MMP-1、COX-2 和 IL-1β 的表达减少，而 TGF-β 的表达增加。
