Alahdal Murad, Duan Li, Ouyang Hongwei, Wang Daping
Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Laboratory of Digital Orthopedic Engineering, Shenzhen Second People's Hospital (The First Hospital Affiliated to Shenzhen University, Health Science Center) Shenzhen 518035, P. R. China.
Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine Hangzhou, P. R. China.
Am J Transl Res. 2020 Jun 15;12(6):2322-2343. eCollection 2020.
Osteoarthritis (OA) is a chronic degenerative joint disease and a leading cause of disability. It involves articular cartilage destruction and a whole joint inflammation. In spite of OA pathogenesis is still unclear, new studies on the OA pathophysiological aetiology and immunomodulation therapy continuously achieve significant advances with new concepts. Here, we focus on the indoleamine-2,3-dioxygenase1 (IDO1) activity in the osteoarthritis (OA), which is one of the noticeable enzymes in the synovial fluid of arthritis patients. It was recognized as an essential mediator of autoreactive B and T cell responses in rheumatoid arthritis (RA) and an interesting therapeutic target against RA. However, the role IDO1 plays in the OA pathogenesis hasn't been discussed. The new OA experimental analysis evidenced IDO1 overexpression in the synovial fluid of OA patients, and recent studies reported that IDO1 metabolites were found higher in the OA synovial fluid than RA and spondyloarthropathies (SpA) patients. Moreover, the positive relation of IDO1 metabolites with OA pain and joint stiffness has been confirmed. Thus, the IDO1 plays a pivotal role in the pathogenesis of OA. In this review, the role IDO1 plays in the OA pathogenesis has been deeply discussed. It could be a promising target in the immunotherapy of OA disease.
骨关节炎（OA）是一种慢性退行性关节疾病，也是导致残疾的主要原因。它涉及关节软骨破坏和整个关节炎症。尽管OA的发病机制仍不清楚，但关于OA病理生理学病因和免疫调节治疗的新研究不断以新的概念取得重大进展。在此，我们聚焦于骨关节炎（OA）中吲哚胺-2,3-双加氧酶1（IDO1）的活性，它是关节炎患者滑液中值得关注的酶之一。它被认为是类风湿关节炎（RA）中自身反应性B和T细胞反应的重要介质，也是针对RA的一个有趣治疗靶点。然而，IDO1在OA发病机制中所起的作用尚未得到讨论。新的OA实验分析证明OA患者滑液中IDO1过表达，并且最近的研究报告称，OA滑液中IDO1代谢产物的含量高于RA和脊柱关节病（SpA）患者。此外，IDO1代谢产物与OA疼痛和关节僵硬之间的正相关关系已得到证实。因此，IDO1在OA发病机制中起关键作用。在本综述中，深入讨论了IDO1在OA发病机制中所起的作用。它可能是OA疾病免疫治疗中有前景的靶点。
