Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Cell Biochem Funct. 2010 Jun;28(4):306-12. doi: 10.1002/cbf.1658.
Leptin regulates body weight, metabolism, and tissue adaptations to environmental stressors. We examined the association of single nucleotide polymorphism (SNP) of leptin promoter G-2548A (rs7799039) and leptin receptor Gln223Arg (rs1137101) with body composition, plasma leptin levels, and peak oxygen uptake (VO(2)peak) in response to 8 weeks of physical training in 48 male military conscripts. AA homozygotes of leptin promoter SNP-2548 showed higher body fat and BMI values than G allele carriers. Acute exercise decreased leptin levels in G allele carriers, but increased in AA homozygotes. Physical training significantly decreased BMI values and also a tendency for decreased plasma leptin levels was observed in all subjects. In G allele carriers, BMI loss was mainly due to decreased fat mass, whereas in AA homozygotes due to loss of fat-free mass. Training increased VO(2)peak in all subjects with most prominent effects in G allele carriers. Regarding leptin receptor SNP, there were no statistically significant differences in BMI values between the genotype groups at baseline or after physical training. Our results suggest that physical training-induced alterations in body composition and plasma leptin may be influenced by a genetic variation of leptin promoter but not of leptin receptor.
瘦素调节体重、新陈代谢和组织对环境应激源的适应。我们研究了瘦素启动子 G-2548A（rs7799039）和瘦素受体 Gln223Arg（rs1137101）的单核苷酸多态性（SNP）与身体成分、血浆瘦素水平和对 8 周身体训练的峰值摄氧量（VO(2)peak）之间的关联在 48 名男性新兵中。瘦素启动子 SNP-2548 的 AA 纯合子比 G 等位基因携带者具有更高的体脂肪和 BMI 值。急性运动降低了 G 等位基因携带者的瘦素水平，但增加了 AA 纯合子的水平。身体训练显著降低了 BMI 值，所有受试者的血浆瘦素水平也呈下降趋势。在 G 等位基因携带者中，BMI 的降低主要是由于脂肪量的减少，而在 AA 纯合子中则是由于无脂肪质量的减少。训练增加了所有受试者的 VO(2)peak，在 G 等位基因携带者中效果最为明显。关于瘦素受体 SNP，在基线或身体训练后，BMI 值在基因型组之间没有统计学上的显著差异。我们的结果表明，身体训练引起的身体成分和血浆瘦素的变化可能受到瘦素启动子的遗传变异的影响，但不受瘦素受体的影响。
