School of Science and Technology, Hellenic Open University, Patras, Greece.
Hum Genomics. 2012 Nov 24;6(1):24. doi: 10.1186/1479-7364-6-24.
The aim of this study was to determine the genotype distribution and allelic frequencies of ACE (I/D), AGTR1 (A +1166 C), BDKRB2 (+9/-9) and LEP (G-2548A) genomic variations in 175 Greek athletes who excelled at a national and/or international level and 169 healthy Greek adults to identify whether some particular combinations of these loci might serve as predictive markers for superior physical condition.
The D/D genotype of the ACE gene (p = 0.034) combined with the simultaneous existence of BDKRB2 (+9/-9) (p = 0.001) or LEP (G/A) (p = 0.021) genotypes was the most prevalent among female athletes compared to female controls. A statistical trend was also observed in BDKRB2 (+9/-9) and LEP (G-2548A) heterozygous genotypes among male and female Greek athletes, and in ACE (I/D) only in male athletes. Finally, both male and female athletes showed the highest rates in the AGTR1 (A/A) genotype.
Our results suggest that the co-existence of ACE (D/D), BDKRB2 (+9/-9) or LEP (G/A) genotypes in female athletes might be correlated with a superior level of physical performance.
本研究旨在确定 ACE（I/D）、AGTR1（A +1166 C）、BDKRB2（+9/-9）和 LEP（G-2548A）基因组变异在 175 名在国家和/或国际水平上表现出色的希腊运动员和 169 名健康希腊成年人中的基因型分布和等位基因频率，以确定这些基因座的某些特定组合是否可能作为优异身体状况的预测标志物。
与女性对照组相比，ACE 基因的 D/D 基因型（p = 0.034）与 BDKRB2（+9/-9）（p = 0.001）或 LEP（G/A）（p = 0.021）基因型的同时存在在女性运动员中最为常见。在男性和女性希腊运动员中，BDKRB2（+9/-9）和 LEP（G-2548A）杂合基因型以及 ACE（I/D）在男性运动员中也观察到了统计学趋势。最后，男性和女性运动员均表现出 AGTR1（A/A）基因型的最高发生率。
我们的结果表明，女性运动员中 ACE（D/D）、BDKRB2（+9/-9）或 LEP（G/A）基因型的共存可能与优异的身体表现水平相关。
