Teff Karen L, Grudziak Joanne, Townsend Raymond R, Dunn Tamara N, Grant Ryan W, Adams Sean H, Keim Nancy L, Cummings Bethany P, Stanhope Kimber L, Havel Peter J
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA.
J Clin Endocrinol Metab. 2009 May;94(5):1562-9. doi: 10.1210/jc.2008-2192. Epub 2009 Feb 10.
Compared with glucose-sweetened beverages, consumption of fructose-sweetened beverages with meals elevates postprandial plasma triglycerides and lowers 24-h insulin and leptin profiles in normal-weight women. The effects of fructose, compared with glucose, ingestion on metabolic profiles in obese subjects has not been studied.
The objective of the study was to compare the effects of fructose- and glucose-sweetened beverages consumed with meals on hormones and metabolic substrates in obese subjects.
The study had a within-subject design conducted in the clinical and translational research center.
Participants included 17 obese men (n = 9) and women (n = 8), with a body mass index greater than 30 kg/m(2).
Subjects were studied under two conditions involving ingestion of mixed nutrient meals with either glucose-sweetened beverages or fructose-sweetened beverages. The beverages provided 30% of total kilocalories. Blood samples were collected over 24 h.
Area under the curve (24 h AUC) for glucose, lactate, insulin, leptin, ghrelin, uric acid, triglycerides (TGs), and free fatty acids was measured.
Compared with glucose-sweetened beverages, fructose consumption was associated with lower AUCs for insulin (1052.6 +/- 135.1 vs. 549.2 +/- 79.7 muU/ml per 23 h, P < 0.001) and leptin (151.9 +/- 22.7 vs. 107.0 +/- 15.0 ng/ml per 24 h, P < 0.03) and increased AUC for TG (242.3 +/- 96.8 vs. 704.3 +/- 124.4 mg/dl per 24 h, P < 0.0001). Insulin-resistant subjects exhibited larger 24-h TG profiles (P < 0.03).
In obese subjects, consumption of fructose-sweetened beverages with meals was associated with less insulin secretion, blunted diurnal leptin profiles, and increased postprandial TG concentrations compared with glucose consumption. Increases of TGs were augmented in obese subjects with insulin resistance, suggesting that fructose consumption may exacerbate an already adverse metabolic profile present in many obese subjects.
与饮用葡萄糖饮料相比，正常体重女性用餐时饮用果糖饮料会使餐后血浆甘油三酯升高，并降低24小时胰岛素和瘦素水平。尚未研究果糖与葡萄糖摄入对肥胖受试者代谢指标的影响。
本研究旨在比较肥胖受试者用餐时饮用果糖饮料和葡萄糖饮料对激素及代谢底物的影响。
本研究采用受试者自身对照设计，在临床与转化研究中心进行。
参与者包括17名肥胖男性（n = 9）和女性（n = 8），体重指数大于30kg/m²。
受试者在两种条件下接受研究，即用餐时饮用葡萄糖饮料或果糖饮料。饮料提供总热量的30%。在24小时内采集血样。
测量葡萄糖、乳酸、胰岛素、瘦素、胃饥饿素、尿酸、甘油三酯（TGs）和游离脂肪酸的曲线下面积（24小时AUC）。
与饮用葡萄糖饮料相比，摄入果糖与胰岛素（每23小时1052.6±135.1对549.2±79.7μU/ml，P < 0.001）和瘦素（每24小时151.9±22.7对107.0±15.0ng/ml，P < 0.03）的AUC降低以及TG的AUC升高（每24小时242.3±96.8对704.3±124.4mg/dl，P < 0.0001）有关。胰岛素抵抗受试者的24小时TG水平更高（P < 0.03）。
在肥胖受试者中，用餐时饮用果糖饮料与胰岛素分泌减少、昼夜瘦素水平降低以及餐后TG浓度升高有关，而饮用葡萄糖饮料则不然。肥胖且有胰岛素抵抗的受试者中TG的升高更为明显，这表明摄入果糖可能会加剧许多肥胖受试者已有的不良代谢状况。
