三七根茎和花总皂苷对肿瘤细胞诱导血小板聚集的影响
[Effect of total saponins from rhizomes and flowers of Panax notoginseng on tumor cell induced platelet aggregation].
作者信息
Ke Yan, Jiang Jia-Ye, Wang Xian-Zhen, Zeng Xiong-Yi, Zhu Chun-Yun
机构信息
Teaching Experimental Center, Shanghai University of TCM, Shanghai 201203, China.
出版信息
Zhong Yao Cai. 2010 Jan;33(1):96-9.
OBJECTIVE
To investigate the effects of total saponins from rhizomes and flowers of Panax notoginseng on tumor cell induced platelet aggregation (TCIPA).
METHODS
MDA-MB-231 breast carcinoma was applied as inductor and the platelet aggregation were investigated by Born's method in vitro and in vivo.
RESULTS
Saponins from the flowers of Panax notoginseng inhibited TCIPA at the dose of 120, 240, 480 mg/L respectively in vitro and in vivo. Saponins from rhizomes of Panax notoginseng inhibited TCIPA only at its high dose in vivo.
CONCLUSION
The saponins from Panax notoginseng has a dose-dependent inhibition of TCIPA. It may be a new class of antimetastatic agent.
目的
研究三七根茎和花总皂苷对肿瘤细胞诱导的血小板聚集（TCIPA）的影响。
方法
以MDA-MB-231乳腺癌细胞作为诱导剂，采用Born法在体外和体内研究血小板聚集情况。
结果
三七花总皂苷在体外和体内分别以120、240、480 mg/L的剂量抑制TCIPA。三七根茎总皂苷仅在体内高剂量时抑制TCIPA。
结论
三七总皂苷对TCIPA具有剂量依赖性抑制作用。它可能是一类新型的抗转移药物。
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