来自喀麦隆的HIV-1 J亚型毒株04CMU11421的近乎全长序列。

Near full-length sequence of HIV type 1 subtype J strain 04CMU11421 from Cameroon.

作者信息

Yamaguchi Julie, Vallari Ana, Ngansop Charlotte, Makamche Florence, Ndembi Nicaise, Mbanya Dora, Kaptué Lazare, Gürtler Lutz G, Devare Sushil G, Brennan Catherine A

机构信息

Abbott Diagnostics, Abbott Park, Illinois, USA.

出版信息

AIDS Res Hum Retroviruses. 2010 Jun;26(6):693-7. doi: 10.1089/aid.2009.0305.

DOI:10.1089/aid.2009.0305

PMID:20518650

Abstract

Although Cameroon, in west central Africa, has a relatively low HIV prevalence of 5-6%, all HIV-1 groups (M, N, O, and P), nearly all HIV-1 group M subtypes, and numerous intersubtype recombinant forms have been identified in Cameroon. In this report, we describe the near full-length sequence of 04CMU11421, an HIV-1 group M subtype J strain collected in Cameroon in 2004. Phylogenetic analysis of the genome sequence shows high bootstrap support with three subtype J reference sequences in the HIV Sequence database. Therefore, 04CMU11421 represents a fourth pure subtype J isolate and the first reported in Cameroon.

摘要

虽然位于非洲中西部的喀麦隆艾滋病毒流行率相对较低，为5%-6%，但在喀麦隆已发现了所有HIV-1组（M、N、O和P）、几乎所有HIV-1组M亚型以及众多亚型间重组形式。在本报告中，我们描述了04CMU11421的近全长序列，这是一株2004年在喀麦隆采集的HIV-1组M亚型J毒株。对该基因组序列的系统发育分析显示，与HIV序列数据库中的三个亚型J参考序列具有较高的自展支持率。因此，04CMU11421代表了第四株纯亚型J分离株，也是喀麦隆首次报告的此类分离株。