秘鲁利马，人免疫缺陷病毒（HIV）患者中无论是否腹泻，致泻性大肠埃希菌的检出率均较高。
High frequency of diarrheagenic Escherichia coli in human immunodeficiency virus (HIV) patients with and without diarrhea in Lima, Peru.
机构信息
Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, San Martin de Porres, Lima, Peru.
出版信息
Am J Trop Med Hyg. 2010 Jun;82(6):1118-20. doi: 10.4269/ajtmh.2010.09-0460.
Diarrhea is still a prevalent health issue in HIV patients. Our objective was to characterize the different diarrheagenic E. coli (DEC) groups in stools from adult HIV patients. Cross sectional study: We enrolled HIV-positive and -negative patients with and without diarrhea from a tertiary-care center of Lima, Peru. Clinical data was recorded and a stool sample per patient was cultured. Multiplex PCR was used to detect different DECs. One hundred eighty-four participants were enrolled. The frequency of having at least one DEC was more common in HIV-positive than HIV-negative patients with diarrhea (42% versus 20%, P < 0.05). The enterotoxigenic E. coli (ETEC) was the most common DEC in patients with diarrhea, 13% in HIV patients. The diffusely adherent E. coli (DAEC) was only present in HIV positive patients with diarrhea (10.1%). Different types of DEC are frequent in stools from HIV-positive patients.
腹泻仍是 HIV 患者普遍存在的健康问题。我们的目的是描述成人 HIV 患者粪便中不同的产毒性大肠杆菌 (DEC) 群。
横断面研究
我们纳入了来自秘鲁利马一家三级护理中心的 HIV 阳性和阴性、有腹泻和无腹泻的患者。记录临床数据，并对每位患者采集一份粪便样本进行培养。采用多重 PCR 检测不同的 DEC。共纳入 184 名参与者。腹泻的 HIV 阳性患者比 HIV 阴性患者至少有一种 DEC 的频率更高（42%对 20%，P < 0.05）。产肠毒素大肠杆菌 (ETEC) 是腹泻患者中最常见的 DEC，HIV 患者中为 13%。弥漫性粘附大肠杆菌 (DAEC) 仅存在于腹泻的 HIV 阳性患者中（10.1%）。不同类型的 DEC 在 HIV 阳性患者的粪便中很常见。
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