Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, San Martin de Porres, Lima, Peru.
Am J Trop Med Hyg. 2010 Jun;82(6):1118-20. doi: 10.4269/ajtmh.2010.09-0460.
Diarrhea is still a prevalent health issue in HIV patients. Our objective was to characterize the different diarrheagenic E. coli (DEC) groups in stools from adult HIV patients. Cross sectional study: We enrolled HIV-positive and -negative patients with and without diarrhea from a tertiary-care center of Lima, Peru. Clinical data was recorded and a stool sample per patient was cultured. Multiplex PCR was used to detect different DECs. One hundred eighty-four participants were enrolled. The frequency of having at least one DEC was more common in HIV-positive than HIV-negative patients with diarrhea (42% versus 20%, P < 0.05). The enterotoxigenic E. coli (ETEC) was the most common DEC in patients with diarrhea, 13% in HIV patients. The diffusely adherent E. coli (DAEC) was only present in HIV positive patients with diarrhea (10.1%). Different types of DEC are frequent in stools from HIV-positive patients.
腹泻仍是 HIV 患者普遍存在的健康问题。我们的目的是描述成人 HIV 患者粪便中不同的产毒性大肠杆菌 (DEC) 群。
我们纳入了来自秘鲁利马一家三级护理中心的 HIV 阳性和阴性、有腹泻和无腹泻的患者。记录临床数据，并对每位患者采集一份粪便样本进行培养。采用多重 PCR 检测不同的 DEC。共纳入 184 名参与者。腹泻的 HIV 阳性患者比 HIV 阴性患者至少有一种 DEC 的频率更高（42%对 20%，P < 0.05）。产肠毒素大肠杆菌 (ETEC) 是腹泻患者中最常见的 DEC，HIV 患者中为 13%。弥漫性粘附大肠杆菌 (DAEC) 仅存在于腹泻的 HIV 阳性患者中（10.1%）。不同类型的 DEC 在 HIV 阳性患者的粪便中很常见。
