探索异三聚体 G 蛋白信号转导。
The quest to understand heterotrimeric G protein signaling.
机构信息
Life Sciences Institute and the Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.
出版信息
Nat Struct Mol Biol. 2010 Jun;17(6):650-2. doi: 10.1038/nsmb0610-650.
Abstract
Over the past fifteen years, great strides have been made to understand how heterotrimeric G proteins control their downstream targets. However, the mechanism by which heterotrimeric G proteins are activated by their upstream G protein-coupled receptors (GPCRs) remains obscure. Recent structural data support the idea that GPCRs, despite their small size, are sophisticated allosteric machines with multiple signaling outputs.
摘要
在过去的十五年中，人们在理解异三聚体 G 蛋白如何控制其下游靶标方面取得了巨大进展。然而，异三聚体 G 蛋白如何被其上游 G 蛋白偶联受体 (GPCR) 激活的机制仍不清楚。最近的结构数据支持这样一种观点，即尽管 GPCR 体积小，但它们是具有多种信号输出的复杂变构机器。
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