Duker J S, Nielsen J, Vander J F, Rosenstein R B, Benson W E
Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston.
Ophthalmology. 1991 Apr;98(4):514-8. doi: 10.1016/s0161-6420(91)32263-2.
The authors conducted a prospective, randomized, double-masked clinical trial to determine if retrobulbar irrigation with bupivacaine hydrochloride 0.75% (Marcaine) has an effect on postoperative pain after scleral buckling surgery. Fifty consecutive patients undergoing scleral buckling under general anesthesia were randomized to receive either bupivacaine or balanced salt solution as a retrobulbar irrigation at the end of their retinal detachment procedure. Of the 25 patients who received bupivacaine, only three (12%) required parenteral pain relief in the first 24 hours after surgery. This was statistically significant when compared with the 18 (72%) of 25 patients requiring parenteral pain relief in the placebo group (P less than 0.0001). In addition, when questioned about their perception of the degree of postoperative pain, patients in the control group rated their level of pain as significantly more severe than did patients in the bupivacaine group. The authors conclude that retrobulbar irrigation with bupivacaine is a safe and effective way to achieve postoperative pain relief after surgery for scleral buckling.
作者进行了一项前瞻性、随机、双盲临床试验,以确定0.75%盐酸布比卡因(耐乐品)球后灌注对巩膜扣带术后疼痛是否有影响。连续50例在全身麻醉下接受巩膜扣带术的患者在视网膜脱离手术结束时被随机分为两组,分别接受布比卡因或平衡盐溶液进行球后灌注。在接受布比卡因的25例患者中,只有3例(12%)在术后24小时内需非肠道途径缓解疼痛。与安慰剂组25例中有18例(72%)需非肠道途径缓解疼痛相比,这具有统计学意义(P小于0.0001)。此外,当询问患者对术后疼痛程度的感受时,对照组患者对疼痛程度的评分明显高于布比卡因组患者。作者得出结论,布比卡因球后灌注是巩膜扣带术后实现疼痛缓解的一种安全有效的方法。