Bourke R D, Dowler J G, Heyworth P, Cooling R J, Moore C
Moorfields Eye Hospital, London, England, United Kingdom.
Retina. 1996;16(3):240-5. doi: 10.1097/00006982-199616030-00010.
Intraoperative retrobulbar bupivacaine injection provides effective analgesia after scleral buckling procedures performed under general anesthesia, but is associated with significant risks.
The safety and analgesic efficacy of an extraconal technique using a blunt cannula was evaluated. Forty patients undergoing scleral buckling procedures with general anesthesia were randomized to intraoperative extraconal bupivacaine injection (bupivacaine group. n = 21) or to no such treatment (control group, n = 19). General anesthetic and postoperative analgesia regimens were standardized. Analgesia requirements, pain, nausea, and sedation levels were graded at four intervals the first 24 hours after surgery. Chemosis was assessed 1 day after surgery, and ocular motility was assessed at 1 day, 1 week, and subsequent review.
Maximum, 0 to 2-hour, and 4 to 6-hour pain levels were lower in the bupivacaine group than the control group (Wilcoxon rank sum, P < 0.005, < 0.005, < 0.01, respectively). Postoperative analgesia was required within the first 24 hours of surgery by all patients in the control group, but by only 12 of 21 patients (57%) in the bupivacaine group (Fisher's exact test, P = 0.001). Ptosis with minimal supraduction defect was noted at first postoperative examination in two patients who had undergone extraconal bupivacaine injection but resolved within 1 week. No other complication was encountered.
Intraoperative extraconal bupivacaine injection appears to be a safe and effective method for reducing pain and analgesia requirements after scleral buckling procedures performed under general anesthesia.
术中球后布比卡因注射可为全身麻醉下进行的巩膜扣带术提供有效的镇痛效果,但存在重大风险。
评估了使用钝头套管的锥体外技术的安全性和镇痛效果。40例接受全身麻醉下巩膜扣带术的患者被随机分为术中锥体外布比卡因注射组(布比卡因组,n = 21)或不进行此类治疗的对照组(n = 19)。全身麻醉和术后镇痛方案标准化。在术后的头24小时内分四个时间段对镇痛需求、疼痛、恶心和镇静水平进行分级。术后1天评估球结膜水肿情况,术后1天、1周及后续复查时评估眼球运动情况。
布比卡因组的最大疼痛水平、0至2小时疼痛水平和4至6小时疼痛水平均低于对照组(分别为Wilcoxon秩和检验,P < 0.005、< 0.005、< 0.01)。对照组所有患者在术后24小时内均需要术后镇痛,而布比卡因组21例患者中只有12例(57%)需要(Fisher精确检验,P = 0.001)。接受锥体外布比卡因注射的两名患者在术后首次检查时出现上睑下垂伴轻度上转受限,但在1周内恢复。未遇到其他并发症。
术中锥体外布比卡因注射似乎是一种安全有效的方法,可减少全身麻醉下进行巩膜扣带术后的疼痛和镇痛需求。