Engineering Controls and Technology Branch (Dr Krajnak, Ms Waugh); Biostatistics and Epidemiology Branch (Mr Sarkisian), National Institute for Occupational Safety and Health, Morgantown, West Virginia.
J Occup Environ Med. 2019 Feb;61(2):162-167. doi: 10.1097/JOM.0000000000001509.
Laser Doppler blood flow measurements have been used for diagnosis or detection of peripheral vascular dysfunction. This study used a rat tail model of vibration-induced vascular injury to determine how laser Doppler measurements were affected by acute and repeated exposures to vibration, and to identify changes in the Doppler signal that were associated with the exposure.
Blood flow was measured immediately after a single exposure to vibration, or before vibration exposure on days 1, 5, 10, 15, and 20 of a 20 days exposure.
After a single exposure to vibration, average tail blood flow was reduced. With 20 days of exposure, there was a reduction in the amplitude of the arterial pulse on days 10 to 20 in vibrated rats and days 15 to 20 in control rats.
More detailed statistical analyses of laser Doppler data may be needed to identify early changes in peripheral circulation after exposure to vibration.
激光多普勒血流测量已被用于诊断或检测外周血管功能障碍。本研究使用振动诱导的血管损伤大鼠尾巴模型，以确定激光多普勒测量值在急性和重复暴露于振动时如何受到影响，并确定与暴露相关的多普勒信号变化。
在单次振动暴露后立即测量血流，或在振动暴露前于第 1、5、10、15 和 20 天进行测量。
单次振动暴露后，平均尾巴血流量减少。经过 20 天的暴露，振动组大鼠在第 10 至 20 天和对照组大鼠在第 15 至 20 天的动脉脉冲振幅降低。
可能需要对激光多普勒数据进行更详细的统计分析，以确定振动暴露后外周循环的早期变化。
