慢性淋巴细胞白血病中的细胞内λ轻链包涵体
Intracellular lambda light chain inclusions in chronic lymphocytic leukaemia.
作者信息
McCann S R, Whelan A, Greally J
出版信息
Br J Haematol. 1978 Mar;38(3):367-71. doi: 10.1111/j.1365-2141.1978.tb01056.x.
Abstract
A case of chronic lymphocytic leukaemia (CLL) with intracytoplasmic crystalline inclusions in peripheral blood lymphocytes is presented. The inclusions were identified as crystals of lambda (lambda) light chain and were present in bone marrow derived (B-cells) lymphocytes. The occurrence of light chain crystals in CLL may reflect a more primitive defect in immunoglobulin (Ig) synthesis, intracellular transport or secretion than has previously been reported.
摘要
本文报告一例慢性淋巴细胞白血病（CLL）患者，其外周血淋巴细胞中存在胞质内结晶包涵体。这些包涵体被鉴定为λ轻链晶体，且存在于骨髓来源的（B细胞）淋巴细胞中。CLL中轻链晶体的出现可能反映了免疫球蛋白（Ig）合成、细胞内运输或分泌方面比之前报道的更为原始的缺陷。
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