Roberts G H, Gordon J, Smith J L, Newell D, Pike R
J Clin Pathol. 1979 Mar;32(3):272-9. doi: 10.1136/jcp.32.3.272.
Lymphocytes from a patient with chronic lymphocytic leukaemia were found to contain crystalline inclusions in the cytoplasm. These crystals were characterised as IgMlambda immunoglobulin. The cells did not have detectable surface immunoglobulin. No paraprotein was detected in the serum and no excess of immunoglobulin was detected in the urine. The cells incorporated radioactive leucine into mu and lambda chains during an 18-hour culture. Studies of labelled lysate immunoglobulin revealed a molar excess of heavy chain over light chain while in contrast free light chain was the only detectable secreted immunoglobulin product during the culture period. These findings are discussed in relation to immunoglobulin synthesis by normal and other neoplastic lymphocyte preparations.
慢性淋巴细胞白血病患者的淋巴细胞被发现细胞质中含有晶体状包涵体。这些晶体被鉴定为IgMλ免疫球蛋白。这些细胞未检测到表面免疫球蛋白。血清中未检测到副蛋白，尿液中也未检测到免疫球蛋白过量。在18小时的培养过程中，这些细胞将放射性亮氨酸掺入μ链和λ链。对标记裂解物免疫球蛋白的研究显示重链摩尔数超过轻链，而相比之下，游离轻链是培养期间唯一可检测到的分泌免疫球蛋白产物。本文结合正常及其他肿瘤淋巴细胞制剂的免疫球蛋白合成对这些发现进行了讨论。
