Rylova A V, Lubnin A Iu, Kutin M A, Beliaev A Iu
Anesteziol Reanimatol. 2010 Mar-Apr(2):36-9.
Today there are prospects for the wide use of xenon for anesthesia or analgesic sedation in neurosurgical patients, but clinical trials of and experience in using the agent in neurosurgery are scanty. The paper reports the first case of acute intracranial hypertension during xenon anesthesia in a patient with a giant brain base tumor and cerebrospinal fluid flow obstruction in the presence of subcompensated intracranial hypertension. Comparison of intracranial pressure, blood pressure, cerebral perfusion pressure, and linear blood flow velocity suggests the nature of the effect of xenon on cerebral vascular tone, cerebral blood flow, and its autoregulation. Based on the findings, the authors discuss whether xenon may be used in patients with intracranial hypertension.
如今，氙气在神经外科患者麻醉或镇痛镇静方面有广泛应用的前景，但在神经外科使用该药物的临床试验和经验却很少。本文报道了首例在存在未完全代偿性颅内高压的情况下，患有巨大脑基底肿瘤且脑脊液流动受阻的患者在氙气麻醉期间发生急性颅内高压的病例。通过比较颅内压、血压、脑灌注压和线性血流速度，揭示了氙气对脑血管张力、脑血流量及其自身调节作用的本质。基于这些发现，作者讨论了氙气是否可用于颅内高压患者。
