Alonso Wilfred Jerome, Sheldon Stephen H
Stanford University, Sleep Disorders Center, Palo Alto, CA, USA.
Pediatr Endocrinol Rev. 2010 Mar-Apr;7(3):292-9.
There is a complex interplay between sleep, metabolism and the function of the endocrine system. A number of endocrine systems are modulated by either the homeostatic drive to sleep, or by the function of the circadian system. As a result, changes in sleep duration and quality have reciprocal effects on hormone secretion and metabolism. In return, sleep disturbance can result from secondary consequences of abnormal endocrine and metabolic function. Inborn errors of metabolism have been demonstrated to have varying effects. The manifestations of lysosomal storage disorders are primarily dependent on the location of substance deposition; resultant effects include disruption of central respiratory control and changes in airway configuration. Neurologic consequences of these disorders include cases of epileptiform discharges in sleep and case reports of non-narcolepsy associated cataplexy.
睡眠、新陈代谢与内分泌系统功能之间存在复杂的相互作用。许多内分泌系统会受到睡眠稳态驱动力或昼夜节律系统功能的调节。因此，睡眠时间和质量的变化会对激素分泌和新陈代谢产生相互影响。反过来，睡眠障碍可能由内分泌和代谢功能异常的继发性后果引起。已证明先天性代谢缺陷具有不同的影响。溶酶体贮积症的表现主要取决于物质沉积的位置；由此产生的影响包括中枢呼吸控制的破坏和气道结构的改变。这些疾病的神经学后果包括睡眠中癫痫样放电的病例以及非发作性睡病相关猝倒的病例报告。
