21st Century Oncology, 801 WH Smith Blvd, Greenville, NC 27834, USA.
Future Oncol. 2010 Jun;6(6):929-40. doi: 10.2217/fon.10.51.
Photodynamic therapy (PDT) is a tumor-ablative and function-sparing oncologic intervention. The relative simplicity of photosensitizer application followed by light activation resulting in the cytotoxic and vasculartoxic photodynamic reaction has allowed PDT to reach a worldwide audience. With several commercially available photosensitizing agents now on the market, numerous well designed clinical trials have demonstrated the efficacy of PDT on various cutaneous and deep tissue tumors. However, current photosensitizers and light sources still have a number of limitations. Future PDT will build on those findings to allow development and refinement of more optimal therapeutic agents and illumination devices. This article reviews the current state of the art and limitations of PDT, and highlight the progress being made towards the future of oncologic PDT.
光动力疗法（PDT）是一种肿瘤消融和功能保留的肿瘤学干预手段。光敏剂的应用相对简单，随后进行光激活，导致细胞毒性和血管毒性光动力反应，这使得 PDT 能够在全球范围内得到应用。目前市场上有几种商业上可用的光敏剂，许多经过精心设计的临床试验已经证明了 PDT 在各种皮肤和深部组织肿瘤中的疗效。然而，目前的光敏剂和光源仍然存在许多局限性。未来的 PDT 将基于这些发现，开发和改进更理想的治疗剂和照明设备。本文综述了 PDT 的现状和局限性，并强调了朝着肿瘤学 PDT 的未来所取得的进展。
