Hanff G, Dahlin L B, Lundborg G
Department of Hand Surgery, Malmö General Hospital, Lund University, Sweden.
Scand J Plast Reconstr Surg Hand Surg. 1991;25(1):25-30. doi: 10.3109/02844319109034919.
Gore-Tex (expanded Polytetrafluoroethylene, E-PTFE) was used to replace the distal pulleys on the proximal phalanges of 20 rabbits. Morphology and function of the reconstructed pulleys were evaluated at 12-20 weeks. The breaking strength of the E-PTFE pulley equalled that of a normal pulley. Range of motion, tendon excursion, and force of flexion were no different from those of normal pulleys. No adhesions between flexor tendons and synovial tendon sheaths or the E-PTFE pulleys could be detected. No adverse tissue reactions were seen. Fibroblast-like cells from the surrounding tissues had grown into the membrane. In other experiments, where the pulleys had been either removed or detached, local fibrosis and adhesions were seen, and the deep flexor tendons had ruptured. The results of the present study indicate that E-PTFE can be used as a biosynthetic replacement for damaged pulleys.
采用戈尔特斯（膨体聚四氟乙烯，E-PTFE）替代20只家兔近节指骨上的远侧滑车。在12至20周时评估重建滑车的形态和功能。E-PTFE滑车的断裂强度与正常滑车相当。活动范围、肌腱移动度和屈肌力量与正常滑车无异。未检测到屈肌腱与滑膜腱鞘或E-PTFE滑车之间有粘连。未见不良组织反应。周围组织的成纤维细胞样细胞已长入该膜。在其他滑车已被切除或分离的实验中，可见局部纤维化和粘连，且指深屈肌腱已断裂。本研究结果表明，E-PTFE可作为受损滑车的生物合成替代品。
