引起菌血症的大肠杆菌分离株中肠毒素的流行情况。
Prevalence of enterotoxins among Escherichia coli isolates causing bacteraemia.
机构信息
Department of Microbiology and Clinical Microbiology, Adnan Menderes University, Aydin, Turkey.
出版信息
FEMS Microbiol Lett. 2010 May;306(2):117-21. doi: 10.1111/j.1574-6968.2010.01945.x.
The most frequent cause of bacteraemia among Gram-negative bacteria is Escherichia coli. Analysis of the genes encoding the Shigella enterotoxin 1 (ShET-1), ShET-2, enteroaggregative heat stable toxin 1 (EAST-1) toxins and AggR factor in E. coli strains causing bacteraemia revealed that set1 genes were presented significantly more frequently among quinolone-susceptible strains (P<0.0001), in phylogenetic group B2 (P=0.0004) and in biofilm strains (P=0.02). In contrast, sen genes were significantly more frequent among nalidixic acid-resistant isolates (15% vs. 6%, P=0.046) and in phylogenetic group B1 (P=0.0001). This is the first study in which ShET1, ShET2 and EAST-1 have been found in E. coli collected from blood.
在革兰氏阴性菌引起的菌血症中，最常见的原因是大肠杆菌。对引起菌血症的大肠杆菌菌株中编码志贺氏肠毒素 1（ShET-1）、ShET-2、肠聚集性耐热毒素 1（EAST-1）毒素和 AggR 因子的基因进行分析表明，set1 基因在喹诺酮敏感株中明显更为常见（P<0.0001），在进化群 B2 中更为常见（P=0.0004），在生物膜株中更为常见（P=0.02）。相比之下，sen 基因在耐萘啶酸的分离株中更为常见（15%比 6%，P=0.046），在进化群 B1 中更为常见（P=0.0001）。这是首次在血液中采集的大肠杆菌中发现 ShET1、ShET2 和 EAST-1。
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