Nutritional Immunology and Molecular Medicine Laboratory; Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA USA.
Gut Microbes. 2013 Jul-Aug;4(4):281-91. doi: 10.4161/gmic.24826. Epub 2013 May 2.
Enteroaggregative Escherichia coli (EAEC) has been acknowledged as an emerging cause of gastroenteritis worldwide for over two decades. Epidemiologists are revealing the role of EAEC in diarrheal outbreaks as a more common occurrence than ever suggested before. EAEC induced diarrhea is most commonly associated with travelers, children and immunocompromised individuals however its afflictions are not limited to any particular demographic. Many attributes have been discovered and characterized surrounding the capability of EAEC to provoke a potent pro-inflammatory immune response, however cellular and molecular mechanisms underlying initiation, progression and outcomes are largely unknown. This limited understanding can be attributed to heterogeneity in strains and the lack of adequate animal models. This review aims to summarize current knowledge about EAEC etiology, pathogenesis and clinical manifestation. Additionally, current animal models and their limitations will be discussed along with the value of applying systems-wide approaches such as computational modeling to study host-EAEC interactions.
肠聚集性大肠杆菌 (EAEC) 作为一种新兴的全球范围食源性致病菌，已经被人们认识了二十多年。流行病学家发现，EAEC 在腹泻爆发中的作用比以往任何时候都更为普遍。EAEC 引起的腹泻最常见于旅行者、儿童和免疫功能低下者，但不限于任何特定的人群。人们已经发现并描述了许多与 EAEC 引起强烈促炎免疫反应相关的特性，然而，其发病机制、进展和结果的细胞和分子机制在很大程度上仍然未知。这种有限的认识可以归因于菌株的异质性和缺乏足够的动物模型。本综述旨在总结目前关于 EAEC 的病因、发病机制和临床表现的知识。此外，还将讨论现有的动物模型及其局限性，以及应用系统范围的方法（如计算建模）来研究宿主- EAEC 相互作用的价值。
