虹膜厚度增加与原发性闭角型青光眼的关系。

Increased iris thickness and association with primary angle closure glaucoma.

机构信息

Singapore Eye Research Institute and Singapore National Eye Center, Singapore.

出版信息

Br J Ophthalmol. 2011 Jan;95(1):46-50. doi: 10.1136/bjo.2009.178129. Epub 2010 Jun 7.

DOI:10.1136/bjo.2009.178129

PMID:20530187

Abstract

AIMS

To investigate the relationship between quantitative iris parameters and angle closure disease. methods: Participants with angle closure were recruited prospectively from glaucoma clinics. Anterior segment optical coherence tomography (AS-OCT) was performed under standardised dark conditions. Customised software was used on horizontal AS-OCT scans to measure iris thickness at 750 um (IT750) and 2000 um (IT2000) from the sclera spur, maximal iris thickness (ITM) and cross-sectional area of the iris (I-Area).

RESULTS

167 Angle closure (consisting of 50 primary angle-closure (PAC), 73 primary angle closure glaucoma (PACG) and 44 fellow eyes of acute PAC) and 1153 normal participants were examined. After adjusting for age, sex, pupil size and anterior chamber depth, mean IT750 (0.499 vs 0.451 mm, p<0.001), IT2000 (0.543 vs 0.479 mm, p<0.001), ITM (0.660 vs 0.602 mm, p<0.001) and I-Area (1.645 vs 1.570 mm(2), p=0.014) were significantly greater in angle closure (combined groups) versus normal eyes. Multivariate adjusted odd ratios (OR) of each parameter for the angle closure as compared with normal eyes were: IT750 OR1.7 (95% CI 1.1 to 2.7, p=0.032); IT2000 OR2.2 (95% CI 1.3 to 3.8, p=0.006) and ITM OR2.2 (95% CI 1.3 to 3.6, p=0.003), respectively, per 0.1 unit increase.

CONCLUSIONS

Increased iris thickness is associated with angle closure.

摘要

目的

探讨定量虹膜参数与闭角型青光眼的关系。方法：前瞻性招募来自青光眼诊所的闭角型青光眼患者。在标准暗室条件下进行眼前节光学相干断层扫描（AS-OCT）。使用定制软件对水平 AS-OCT 扫描进行分析，以测量巩膜突 750 um（IT750）和 2000 um（IT2000）处的虹膜厚度、最大虹膜厚度（ITM）和虹膜横截面积（I-Area）。结果：共纳入 167 例闭角型青光眼（包括 50 例原发性闭角型青光眼（PAC）、73 例原发性闭角型青光眼（PACG）和 44 例急性 PAC 的对侧眼）和 1153 例正常对照者。校正年龄、性别、瞳孔大小和前房深度后，闭角型青光眼组平均 IT750（0.499 vs 0.451 mm，p<0.001）、IT2000（0.543 vs 0.479 mm，p<0.001）、ITM（0.660 vs 0.602 mm，p<0.001）和 I-Area（1.645 vs 1.570 mm(2)，p=0.014）均显著大于正常对照组。与正常眼相比，每个参数的多变量调整比值比（OR）为：IT750 OR1.7（95% CI 1.1 至 2.7，p=0.032）；IT2000 OR2.2（95% CI 1.3 至 3.8，p=0.006）和 ITM OR2.2（95% CI 1.3 至 3.6，p=0.003），每增加 0.1 单位。结论：虹膜厚度增加与闭角型青光眼有关。