Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Antimicrob Agents Chemother. 2010 Sep;54(9):3569-77. doi: 10.1128/AAC.00057-10. Epub 2010 Jun 7.
Multidrug resistance has emerged as a significant concern with infections caused by Acinetobacter baumannii. Ample evidence supports the involvement of mobile genetic elements in the transfer of antibiotic resistance genes, but the extent of variability and the rate of genetic change associated with the acquisition of antibiotic resistance have not been studied in detail. Whole-genome sequence analysis of six closely related clinical isolates of A. baumannii, including four from the same hospital, revealed extensive divergence of the resistance genotype that correlated with observed differences in antimicrobial susceptibility. Resistance genes associated with insertion sequences, plasmids, and a chromosomal resistance gene island all showed variability. The highly dynamic resistance gene repertoire suggests rapid evolution of drug resistance.
多重耐药性已成为鲍曼不动杆菌感染的一个重大问题。大量证据表明，移动遗传元件参与了抗生素耐药基因的转移，但抗生素耐药性获得相关的遗传变异性和遗传变化率尚未得到详细研究。对 6 株密切相关的鲍曼不动杆菌临床分离株（包括 4 株来自同一医院的分离株）进行全基因组序列分析，结果显示耐药基因型广泛分化，与观察到的抗菌药物敏感性差异相关。与插入序列、质粒和染色体耐药基因岛相关的耐药基因均表现出可变性。高度动态的耐药基因库表明，耐药性迅速进化。
