Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy.
IUBMB Life. 2011 Dec;63(12):1068-74. doi: 10.1002/iub.531. Epub 2011 Oct 27.
The genome sequences of a number of Acinetobacter baumannii strains, including representatives of the main epidemic international lineages, have now been determined, and several others are in progress. The study of A. baumannii genomics has provided an expanded view of the adaptation and virulence capacities of this bacterial species, whilst also presenting novel insights into its intraspecies diversity and genome evolution. Genomic analyses have revealed that the current A. baumannii clinical population consists of low-grade pathogens, whose pathogenicity relies mainly on an ability to persist in the hospital setting and survive antibiotic treatment. A. baumannii has a high capacity to acquire new genetic determinants and displays an open pan genome; this feature may have played a crucial role in the evolution of this human opportunistic pathogen towards clinical success.
目前已经确定了许多鲍曼不动杆菌菌株的基因组序列，包括主要国际流行谱系的代表，还有其他一些正在进行中。对鲍曼不动杆菌基因组学的研究提供了对该细菌物种适应和毒力能力的扩展视图，同时也揭示了其种内多样性和基因组进化的新见解。基因组分析表明，目前的鲍曼不动杆菌临床人群由低级别病原体组成，其致病性主要依赖于在医院环境中生存和对抗生素治疗产生抗性的能力。鲍曼不动杆菌具有很高的获取新遗传决定因素的能力，并表现出开放的泛基因组；这一特征可能在这种人类机会性病原体向临床成功的进化中发挥了关键作用。
