Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China.
Diabetes Care. 2010 Sep;33(9):1925-32. doi: 10.2337/dc10-0340. Epub 2010 Jun 8.
Elevated lipopolysaccharide-binding protein (LBP), a marker of subclinical endotoxemia, may be involved in the pathogenesis of obesity and metabolic risk. We aimed to investigate the association between plasma LBP and metabolic disorders in apparently healthy Chinese.
A population-based study including 559 overweight/obese (BMI >or=24.0 kg/m(2)) and 500 normal-weight (18.0 <or= BMI <24.0 kg/m(2)) subjects aged 35-54 years was conducted in Shanghai, China. Fasting plasma glucose, lipid profile, LBP, high-sensitivity C-reactive protein, interleukin-6, high-molecular-weight (HMW) adiponectin, leptin, hepatic enzymes, and body composition were measured. Metabolic syndrome was defined by the updated National Cholesterol Education Program Adult Treatment Panel III criterion for Asian Americans.
LBP levels were significantly higher in overweight/obese individuals than in normal-weight individuals (geometric mean 27.6 [95% CI 25.2-30.3] vs. 10.0 [9.1-11.1] microg/ml; P < 0.001). After multiple adjustments including BMI, the odds ratios were 3.54 (95% CI 2.05-6.09) and 5.53 (95% CI 2.64-11.59) for metabolic syndrome and type 2 diabetes, respectively, comparing the highest with the lowest LBP quartile. Further adjustments for inflammatory markers almost abolished the significant association of LBP with metabolic syndrome but not that with type 2 diabetes, and controlling for adipokines and hepatic enzymes did not substantially alter the results.
Elevated circulating LBP was associated with obesity, metabolic syndrome, and type 2 diabetes in apparently healthy Chinese. These findings suggested a role of lipopolysaccharide via initiation of innate immune mechanism(s) in metabolic disorders. Prospective studies are needed to confirm these results.
内毒素血症的标志物脂多糖结合蛋白（LBP）升高可能与肥胖和代谢风险的发病机制有关。我们旨在研究血浆 LBP 与中国貌似健康人群代谢紊乱的关系。
在中国上海进行了一项基于人群的研究，纳入 559 名超重/肥胖（BMI≥24.0kg/m2）和 500 名体重正常（18.0≤BMI＜24.0kg/m2）的 35-54 岁人群。检测空腹血糖、血脂、LBP、高敏 C 反应蛋白、白细胞介素-6、高分子量（HMW）脂联素、瘦素、肝酶和体成分。代谢综合征按亚洲人美国国家胆固醇教育计划成人治疗小组 III 标准的最新版本定义。
超重/肥胖者的 LBP 水平明显高于体重正常者（几何均数 27.6[95%CI 25.2-30.3] vs. 10.0[9.1-11.1]μg/ml；P＜0.001）。经过包括 BMI 在内的多重调整，LBP 四分位数最高与最低组相比，代谢综合征和 2 型糖尿病的比值比分别为 3.54（95%CI 2.05-6.09）和 5.53（95%CI 2.64-11.59）。进一步调整炎症标志物几乎消除了 LBP 与代谢综合征的显著关联，但对 2 型糖尿病无显著关联，而控制脂联素和肝酶并没有显著改变结果。
循环 LBP 升高与中国貌似健康人群的肥胖、代谢综合征和 2 型糖尿病有关。这些发现表明，内毒素通过启动先天免疫机制在代谢紊乱中起作用。需要前瞻性研究来证实这些结果。
