Halbmayer W M, Hopmeier P, Mannhalter C, Heuss F, Leodolter S, Rubi K, Fischer M
Central Laboratory, Municipal Hospital of the City of Vienna-Lainz, Austria.
Thromb Haemost. 1991 Feb 12;65(2):134-8.
Routine coagulation tests and measurement of the plasma levels of C1-esterase inhibitor (C1-INH) and antithrombin III were performed in 17 women with mild preeclampsia, 10 women with moderate preeclampsia and 20 women with uncomplicated pregnancy. All pregnant probands were within the third trimester of pregnancy. 20 non-pregnant women were used as controls. The groups were matched in age and the pregnant ones were also matched in gestational age. C1-INH activity and antigen were significantly reduced (p less than 0.002) in normally pregnant women as compared with non-pregnant ones. Further, C1-INH activity was lower in women with mild preeclampsia and significantly lower in women with moderate preeclampsia (p less than 0.05) as compared with normally pregnant women. None of the plasmatic coagulation tests was indicative of a consumption reaction. We conclude that C1-INH activity and antigen reductions are commonly associated with pregnancy. Furthermore, as markedly lower values can be found in mild and moderate preeclampsia, measurement of the C1-INH activity in pregnant women within the third trimester might proof useful to establish the diagnosis of a preeclamptic condition.
对17例轻度子痫前期孕妇、10例中度子痫前期孕妇和20例正常妊娠孕妇进行了常规凝血试验，并检测了血浆中C1酯酶抑制剂（C1-INH）和抗凝血酶III的水平。所有孕妇均处于妊娠晚期。选取20例非妊娠女性作为对照。各研究组年龄匹配，孕妇的孕周也相互匹配。与非妊娠女性相比，正常妊娠女性的C1-INH活性和抗原显著降低（p<0.002）。此外，与正常妊娠女性相比，轻度子痫前期女性的C1-INH活性较低，中度子痫前期女性的C1-INH活性显著更低（p<0.05）。所有血浆凝血试验均未提示存在消耗反应。我们得出结论，C1-INH活性和抗原降低通常与妊娠有关。此外，由于在轻度和中度子痫前期可发现C1-INH活性值明显更低，因此在妊娠晚期测量孕妇的C1-INH活性可能有助于子痫前期的诊断。
