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2 型糖尿病退伍军人全因死亡率的种族差异。

Racial disparities in all-cause mortality among veterans with type 2 diabetes.

机构信息

Center for Disease Prevention and Health Interventions for Diverse Populations, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA.

出版信息

J Gen Intern Med. 2010 Oct;25(10):1051-6. doi: 10.1007/s11606-010-1405-y. Epub 2010 Jun 8.

Abstract

BACKGROUND

Racial differences in mortality among veterans with diabetes are less well characterized than those in the general population.

OBJECTIVE

To examine racial differences in all-cause mortality in a large sample of veterans with diabetes.

DESIGN

A retrospective cohort.

PARTICIPANTS

Participants comprised 8,812 veterans with type 2 diabetes.

MEASUREMENTS

The main outcome measure was time to death. The main predictor was race/ethnicity. Other risk factors (or covariates) included age, gender, marital status, employment, glycosylated hemoglobin (HgbA1c), and several ICD-9 coded physical and mental health comorbidities.

RESULTS

Average follow-up was 4.5 years; 64% of veterans were non-Hispanic whites (NHW), 97% male, and 84% at least 50 years old. The overall mortality rate was 15% and was significantly lower for non-Hispanic blacks (NHB). Baseline HgbA1c values also differed for NHW (mean = 7.05) and NHB (mean = 7.65) (p < 0.001). In sequentially-built models NHB race was associated with a lower risk of mortality with HR ranging 0.80-0.92. After adjusting for all significant covariates, the risk of mortality remained lower for NHB (HR = 0.84, 95% CI: 0.75, 0.94). Increased mortality risk was associated with age, not being employed or retired, poor glycemic control, cancer, Coronary Heart Disease (CHD), and anxiety disorder; while a lower risk was associated with being female and ever being married.

CONCLUSIONS

The risk of death among NHB veterans with diabetes remained significantly lower than that of NHW after controlling for important confounding variables. Future studies in the VA need to examine detailed contributions of patient, provider and system-level factors on racial differences in mortality in adults with diabetes, especially if the findings of this study are replicated at other sites or using national VA data.

摘要

背景

与普通人群相比,糖尿病退伍军人的死亡率种族差异的特征描述还不够完善。

目的

在一个大型糖尿病退伍军人样本中研究全因死亡率的种族差异。

设计

回顾性队列。

参与者

参与者包括 8812 名 2 型糖尿病退伍军人。

测量

主要结局指标是死亡时间。主要预测因子是种族/民族。其他风险因素(或协变量)包括年龄、性别、婚姻状况、就业、糖化血红蛋白(HgbA1c)以及几种 ICD-9 编码的身体和心理健康合并症。

结果

平均随访时间为 4.5 年;64%的退伍军人为非西班牙裔白人(NHW),97%为男性,84%至少 50 岁。总体死亡率为 15%,非西班牙裔黑人(NHB)的死亡率明显较低。NHW(平均=7.05)和 NHB(平均=7.65)的基线 HgbA1c 值也存在差异(p<0.001)。在逐步构建的模型中,NHB 种族与死亡率风险降低相关,HR 范围为 0.80-0.92。在调整所有显著协变量后,NHB 的死亡率风险仍然较低(HR=0.84,95%CI:0.75,0.94)。年龄增加、未就业或退休、血糖控制不佳、癌症、冠心病(CHD)和焦虑障碍与死亡风险增加相关;而女性和已婚的风险较低。

结论

在控制重要混杂变量后,NHB 糖尿病退伍军人的死亡风险仍明显低于 NHW。VA 中的未来研究需要检查患者、提供者和系统层面因素对糖尿病成年人死亡率种族差异的详细影响,特别是如果本研究的结果在其他地点或使用国家 VA 数据得到复制。

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