Department of Parasitology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Planta Med. 2010 Nov;76(16):1852-8. doi: 10.1055/s-0030-1249971. Epub 2010 Jun 8.
In this study, we investigated the anthelmintic activity of [10]-shogaol, [6]-shogaol, [10]-gingerol and [6]-gingerol, compounds isolated from the roots of Zingiber officinale L., Zingiberaceae (ginger), against Anisakis simplex. The above compounds kill or reduce spontaneous movement in A. simplex larvae. The maximum lethal efficacy of [10]-shogaol and [10]-gingerol was approximately 80% and 100%, respectively. We further examined the time course of compound-induced loss of mobility in A. simplex. The results showed that various concentrations of [10]-shogaol, [6]-shogaol, [10]-gingerol and [6]-gingerol have maximum effects on loss of spontaneous movement from 24 to 72 h. In addition, the time course of mortality and the percentage of loss of spontaneous movements were ascertained to determine the minimum effective doses of [10]-gingerol and [10]-shogaol. [10]-Gingerol exhibited a larger maximum larvicidal effect and greater loss of spontaneous movement than [10]-shogaol and albendazole. In addition, these constituents of Zingiber officinale showed effects against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and peroxyl radicals. These constituents of Zingiber officinale are responsible for its larvicidal activity against A. simplex.
在这项研究中，我们研究了从姜科植物姜根茎中分离得到的[10]-姜烯酚、[6]-姜烯酚、[10]-姜醇和[6]-姜醇对食源性寄生虫线虫简单异尖线虫的驱虫活性。上述化合物可杀死或减少简单异尖线虫幼虫的自发运动。[10]-姜烯酚和[10]-姜醇的最大致死功效分别约为 80%和 100%。我们进一步研究了化合物诱导简单异尖线虫运动能力丧失的时间过程。结果表明，[10]-姜烯酚、[6]-姜烯酚、[10]-姜醇和[6]-姜醇的各种浓度在 24 至 72 小时内对自发运动丧失具有最大的影响。此外，还确定了死亡率和自发运动丧失百分比的时间过程，以确定[10]-姜醇和[10]-姜烯酚的最小有效剂量。[10]-姜醇表现出比[10]-姜烯酚和阿苯达唑更大的最大幼虫杀伤作用和更大的自发运动丧失。此外，这些姜属成分对 2,2-二苯基-1-苦基肼（DPPH）和过氧自由基也有作用。这些姜属成分是其对简单异尖线虫幼虫具有驱虫活性的原因。
